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| Status |
Public on Dec 23, 2019 |
| Title |
Gene Expressions responsible for good response to Nivolumab treatment |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Analysis of gene expression in CD62Lhigh CD4+ T cells and CD62Llow CD4+ T cells from good responder (GR), intermediate responder (IR), and non-responder (NR).
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| Overall design |
PBMC were obtained from two of each responder group; good responders, intermediate responders, and non-responders. CD4+ T cells were purified by negative selection using human CD4+ T cell isolation kits. CD4+ T cells were further separated into CD62Lhigh cells and CD62Llow cells by anti-CD62L mAb-coated microbeads and MACSTM system. We have invetigated the differences of gene expresion between CD62L high and low CD4+ Tcell from three kinds of patients groups.
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| Contributor(s) |
Kagamu H, Horimoto K, Kitazawa M |
| Citation(s) |
31871122 |
| Submission date |
Aug 28, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
Masashi Kitazawa |
| E-mail(s) |
masashi-kitazawa@aist.go.jp
|
| Organization name |
National of Institute of Advanced Industrial Science and Technology (AIST)
|
| Street address |
2-4-7 Aomi
|
| City |
Koto-ku, |
| State/province |
Tokyo |
| ZIP/Postal code |
135-0064 |
| Country |
Japan |
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| Platforms (1) |
| GPL23159 |
[Clariom_S_Human] Affymetrix Clariom S Assay, Human (Includes Pico Assay) |
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| Samples (12)
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| GSM2756250 |
CD62L high CD4+ T cells from good responder of patient 1; ICI-39 |
| GSM2756251 |
CD62L high CD4+ T cells from good responder of patient 2; ICI-44 |
| GSM2756252 |
CD62L high CD4+ T cells from intermediate responder of patient 1; ICI-17 |
| GSM2756253 |
CD62L high CD4+ T cells from intermediate responder of patient 2; ICI-56 |
| GSM2756254 |
CD62L high CD4+ T cells from non-responder of patient 1; ICI-21 |
| GSM2756255 |
CD62L high CD4+ T cells from non-responder of patient 2; ICI-52 |
| GSM2756256 |
CD62L low CD4+ T cells from good responder of patient 1; ICI-39 |
| GSM2756257 |
CD62L low CD4+ T cells from good responder of patient 2; ICI-44 |
| GSM2756258 |
CD62L low CD4+ T cells from intermediate responder of patient 1; ICI-17 |
| GSM2756259 |
CD62L low CD4+ T cells from intermediate responder of patient 2; ICI-56 |
| GSM2756260 |
CD62L low CD4+ T cells from non-responder of patient 1; ICI-21 |
| GSM2756261 |
CD62L low CD4+ T cells from non-responder of patient 2; ICI-52 |
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| Relations |
| BioProject |
PRJNA400373 |
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