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| Status |
Public on Oct 25, 2017 |
| Title |
UTX/KDM6A Loss Enhances the Malignant Phenotype of Multiple Myeloma and Sensitizes Cells to EZH2 inhibition |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
In this project we analyze the transcriptome of the human multiple myeloma isogenic cell lines ARP-1 (UTX wild-type) and ARD (UTX null). The transcriptome is studied at baseline, upon restoration of UTX levels in ARD cells for 3 and 6 days, and upon treatment of the cell lines with the EZH2 inhibitor GSK343. Moreover, we analyzed the transcriptome of a ARD resistant cell line that we generated.
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| |
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| Overall design |
Examination of transcriptome of two cell lines upon restoration of UTX and treatment with EZH2 inhibitors
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| |
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| Contributor(s) |
Ezponda T, Licht JD |
| Citation(s) |
29045832 |
| Submission date |
Sep 06, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Teresa Ezponda |
| E-mail(s) |
tezponda@gmail.com
|
| Organization name |
Center for Applied Medical Research
|
| Department |
Hematology/Oncology
|
| Lab |
1.02
|
| Street address |
Pio XII 55
|
| City |
Pamplona |
| State/province |
Navarra |
| ZIP/Postal code |
31008 |
| Country |
Spain |
| |
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| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
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| Samples (22)
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| Relations |
| BioProject |
PRJNA401933 |
| SRA |
SRP116930 |
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