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Series GSE104244 Query DataSets for GSE104244
Status Public on Sep 27, 2017
Title Bone Marrow Derived Macrophages, NSCLC cell lines, and Kras G12D Lung Tumors Treated with Epigenetic Agents
Organisms Homo sapiens; Mus musculus
Experiment type Expression profiling by array
Summary Transcriptional profiling of Aza+ITF-2357 treated bone marrow derived macrophages vs. Mock treated bone marrow derived macrophages. Aim was to elucidate the effects of epigentic drug treatment on in vitro cultured macrophages and to compare these data to in vivo treated macrophage populations.
Transcriptional profiling of NSCLC cell lines treated with epigenetic agents
Transcriptional profiling of immune populations in the lung Kras G12D tumor micronevironment treated with combination epigenetic therapy
Transcriptional profiling of lung Kras G12D tumors treated with combination epigenetic therapy
 
Overall design Two color array representation of two-condition experiment Aza+ITF-2357 treated bone marrow derived macrophages vs. Mock treated bone marrow derived macrophages. Data are single array representation of 3 pooled bone marrow derived macrophage replicates for each condition.
Two-condition experiment, Mock vs. MS-275, Mock vs. ITF-2357, Mock vs. Azacitidine, Mock vs. Azacitidine+MS-275, Mock vs. Azacitidine+ITF-2357
Two-condition experiment: Mock vs. 0.5mg/kg Azacitidine + 2.0mg/kg ITF-2357. Populations assayed in this experiment: Macrophages- CD45+, CD11b+, F4/80+; T lymphocytes: CD45+, CD3+, CD8+
Two-condition experiment, Mock vs. 0.5mg/kg Azacitidine + 2.0mg/kg ITF-2357
 
Contributor(s) Topper M
Citation(s) 29195073
Submission date Sep 26, 2017
Last update date Jul 25, 2021
Contact name Michael Jonathan Topper
Organization name Johns Hopkins University
Department Oncology
Street address 1650 Orleans St., Suite 530
City Baltimore
State/province MD
ZIP/Postal code 21287
Country USA
 
Platforms (2)
GPL11202 Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version)
GPL13497 Agilent-026652 Whole Human Genome Microarray 4x44K v2 (Probe Name version)
Samples (33)
GSM2793707 Combination Treated Bone Marrow Derived Macrophages
GSM2876286 H460 Mock v. 100nM MS-275 rep1
GSM2876287 H460 Mock v. 100nM ITF-2357 rep1
Relations
BioProject PRJNA412162

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE104244_RAW.tar 430.1 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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