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| Status |
Public on Nov 02, 2017 |
| Title |
Fibrinogen activates BMP signaling in oligodendrocyte progenitor cells (OPCs) and inhibits remyelination after vascular damage [Rat_OPC_48h_Fibrinogen] |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
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| Summary |
Determination of the mechanism by which fibrinogen, a central blood coagulation protein, regulates OPC functions and remyelination in the CNS.
We used microarrays to determine the genes involved in OPC responses to fibrinogen, which is deposited in the CNS after blood-brain barrier disruption.
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| Overall design |
Primary rat OPCs were stimulated with fibrinogen for 48 hr and subjected to RNA extraction and hybridization on Affymatrix microarrays. Three unstimulated and three fibrinogen-stimulated samples were generated.
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| Contributor(s) |
Akassoglou K, Petersen M |
| Citation(s) |
29103804 |
| Submission date |
Sep 29, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
Mark Petersen |
| E-mail(s) |
mark.petersen@gladstone.ucsf.edu
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| Organization name |
Gladstone Institutes
|
| Street address |
1650 Owens Street
|
| City |
San Francisco |
| ZIP/Postal code |
94158 |
| Country |
USA |
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| Platforms (1) |
| GPL6247 |
[RaGene-1_0-st] Affymetrix Rat Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (6)
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| This SubSeries is part of SuperSeries: |
| GSE104450 |
Fibrinogen activates BMP signaling in oligodendrocyte progenitor cells (OPCs) and inhibits remyelination after vascular damage |
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| Relations |
| BioProject |
PRJNA412656 |
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