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Series GSE10533 Query DataSets for GSE10533
Status Public on Dec 28, 2008
Title Effects of spaceflight on murine skeletal muscle gene expression
Organism Mus musculus
Experiment type Expression profiling by array
Summary Spaceflight results in a number of adaptations to skeletal muscle, including atrophy and shifts towards faster muscle fiber types. To identify changes in gene expression that may underlie these adaptations, microarray expression analysis was performed on gastrocnemius from mice flown on the STS-108 shuttle flight (11 days, 19 hours) versus mice maintained on earth for the same period. Additionally, to identify changes that were due to unloading and reloading, microarray analyses were conducted on calf muscle from ground-based mice subjected to hindlimb suspension (12 days) and mice subjected to hindlimb suspension plus a brief period of reloading (3.5 hours) to simulate the time between landing and sacrifice of the spaceflight mice.
 
Overall design There are five experimental groups in this study: 1) mouse gastrocnemius, spaceflight for 11 days 19hr, n=4; 2) mouse gastrocnemius, animal enclosure module for 11 days, 19h, n=4; 3) mouse calf muscle, hindlimb suspension for 12 days, n=5; 4) mouse calf muscle, hindlimb suspension for 12 days plus reloading for 3.5 hr, n=5; 5) mouse calf muscle, no experimental treatment, n=5.
 
Contributor(s) Allen DA, Bateman TA, Barth JL
Citation(s) 19074574
Submission date Feb 14, 2008
Last update date Jan 08, 2019
Contact name Jeremy Barth
E-mail(s) barthj@musc.edu
Organization name MUSC
Street address 173 Ashley Ave, BSB 627
City Charleston
State/province SC
ZIP/Postal code 29425-5080
Country USA
 
Platforms (1)
GPL339 [MOE430A] Affymetrix Mouse Expression 430A Array
Samples (23)
GSM266034 Muscle control 19
GSM266035 Muscle control 1
GSM266036 Muscle control 21
Relations
BioProject PRJNA107887

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Supplementary file Size Download File type/resource
GSE10533_RAW.tar 69.8 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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