NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE106081 Query DataSets for GSE106081
Status Public on Jun 04, 2020
Title Transcriptional Analysis of Type II Alveolar Epithelial Cells in the Presence or Absence of Foxp3+ Regulatory T Cells during Experimental Acute Lung Injury Resolution
Organism Mus musculus
Experiment type Expression profiling by array
Summary These studies profiled the expression of mRNA in lung type II alveolar epithelial cells during lipopolysacchride induced lung injury in the presence or absence of Foxp3+ Regulatory T Cells
Baseline, uninjured lung type II alveolar epithelial (AT2) cells or resolving AT2 cells, in the presence or absence of Foxp3+ regulatory T cells (Tregs), were sorted (7 days after intratracheal instillation of LPS for resolving conditions) and mRNAs differentially expressed (DE) between control AT2 cells, resolving AT2 cells with Tregs present, or resolving AT2 cells in mice depleted of Tregs were identified using microarrays.
 
Overall design Control lung type II alveolar epithelial (AT2) cells or two sets of AT2 cells obtained during a time point of lung injury resolution either in the presence or absence of regulatory T cells were sorted for mRNA analysis. mRNA expression was profiled using Mouse Gene 2.1 ST arrays (Affymetrix, Santa Clara, CA) which cover over 28,000 RefSeq transcripts
 
Contributor(s) Mock JR, Dang H, Doerschuk CM
Citation(s) 32543909
NIH grant(s)
Grant ID Grant title Affiliation Name
K12 HL119998 Application of Omics in Lung Disease UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL Claire M Doerschuk
K08 HL129075 Regulatory T Cells Promote Alveolar Epithelial Repair UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL Jason Robert Mock
R03 HL145255 Defining the Role of Regulatory T Cell-Derived MMP12 in Acute Lung Injury Resolution UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL Jason Robert Mock
Submission date Oct 24, 2017
Last update date Sep 03, 2020
Contact name Jason Robert Mock
E-mail(s) jason_mock@med.unc.edu
Phone 9199625347
Organization name University of North Carolina
Department Internal Medicine
Street address 125 Mason Farm Rd, Marsico Hall 7229G
City Chapel Hill
State/province North Carolina
ZIP/Postal code 27599
Country USA
 
Platforms (1)
GPL22070 [MoGene-2_1-st] Affymetrix Mouse Gene 2.1 ST Array [transcript-level na35ens81]
Samples (15)
GSM2829248 WT1
GSM2829249 WT2
GSM2829250 WT3
Relations
BioProject PRJNA415567

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE106081_Mock_AT2_RMA_Matrix.xlsx 7.8 Mb (ftp)(http) XLSX
GSE106081_RAW.tar 64.2 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table
Processed data are available on Series record

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap