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| Status |
Public on Mar 01, 2018 |
| Title |
An evolutionarily conserved ribosome-rescue pathway maintains epidermal homeostasis |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
mRNA quality control mechanisms ensure fidelity of protein translation. An evolutionarily conserved component of the quality control machinery, Dom34/Pelota (Pelo), rescues stalled ribosomes. Here we show that Pelo is required for mammalian epidermal homeostasis. Our study reveals a novel role for the ribosome-rescue machinery in mammalian tissue homeostasis and an unanticipated specificity in its impact on different stem cell populations.
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| |
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| Overall design |
RNA-seq of mouse epidermal stem cell subpopulations (Lrig1+, Lgr5+ and Lgr6+) in WT and Pelota KO mice. We have triplicates for each experimental condition.
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| Contributor(s) |
Liakath-Ali K, Oliveira Pisco A, Sequeira I, Watt FM |
| Citation(s) |
29643507 |
| Submission date |
Oct 26, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Angela Oliveira Pisco |
| E-mail(s) |
angela.pisco@czbiohub.org
|
| Organization name |
CZ Biohub
|
| Department |
Data Sciences
|
| Street address |
499 Illinois St
|
| City |
San Francisco |
| State/province |
CA |
| ZIP/Postal code |
94103 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
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| Samples (17)
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| Relations |
| BioProject |
PRJNA415988 |
| SRA |
SRP121790 |
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