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| Status |
Public on Nov 04, 2021 |
| Title |
Identifying biomarkers predicting response to chemotherapy in Stage II and Stage III colorectal cancer patients |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Defining molecular features that can predict the response to chemotherapy for stage II-III colorectal cancer (CRC) patients remains challenging in cancer research. Most available clinical samples are Formalin-Fixed and Paraffin-Embedded (FFPE). Affymetrix GeneChip® Human Transcriptome Array 2.0 (HTA) is one platform marketed for high-throughput gene expression profiling for FFPE tissue samples. In this study, we analyzed the whole transcriptom gene expression of 156 CRC patient samples measured by this platform to identify biomarkers predicting the response to chemotherapy for stage II-III CRC patients.
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| Overall design |
In this study, we measured the whole transcriptom gene expression of 156 CRC patient samples (Stage I to Stage IV) based on HTA platform.
The disease status was provided in each sample characteristics field as following;
no evidence of disease (NED)
alive with disease (AWD)
dead of disease (DOD)
dead of unrelated causes (DOC)
The values 0 and 1 for the sample characteristics represent NO and YES, respectively.
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| |
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| Contributor(s) |
Zhu J, Deane NG, Lewis KB, Padmanabhan C, Washington MK, Shi C, Ciombor KK, Timmers C, Goldberg RM, Chen X, Beauchamp RD |
| Citation(s) |
27623752 |
| NIH grant(s) |
| Grant ID |
Grant title |
Affiliation |
Name |
| R01 CA158472 |
Integrative prediction models for metastasis risk in colon cancer |
University of Miami School of Medicine |
Xi Steven Chen |
|
| Submission date |
Nov 06, 2017 |
| Last update date |
Feb 03, 2022 |
| Contact name |
Xi CHEN |
| Organization name |
University of Miami
|
| Street address |
1120 NW 14th Street
|
| City |
MIAMI |
| State/province |
FL |
| ZIP/Postal code |
33136 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL17586 |
[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version] |
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| Samples (156)
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| Relations |
| BioProject |
PRJNA417287 |
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