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Series GSE106727 Query DataSets for GSE106727
Status Public on Jan 27, 2020
Title MYCN Drives Disparate Medulloblastoma from Human Embryonic and iPSC-Derived Stem Cells [array]
Organism Homo sapiens
Experiment type Methylation profiling by genome tiling array
Summary How tumors develop or respond to therapies vary significantly among species. Here we report that medulloblastoma (MB) the most frequent malignant childhood brain tumor can develop from human hindbrain neuro-epithelial stem (hbNES) cells or induced pluripotent stem cell (iPSC)-derived NES (NES) cells via MYCN overexpression in mice. NES tumors developed fast with leptomeningeal dissemination, while hbNES tumors formed significantly later with no dissemination. By using large cohorts of MB patients we show that tumors resemble a common subgroup of Sonic Hedgehog (SHH) MBs and that pluripotency and mTOR signaling correlate with poor prognosis. To conclude, both iPSC-derived and embryonic NES cells can be transformed into distinct humanized MB models valuable for identifying better diagnostic markers and drug targets.
 
Overall design Total of 18 snap frozen tumor model biopsies were profiled for DNA methylation.
 
Contributor(s) Čančer M, Hutter S, Rosén G, Sundström A, Tailor J, Garancher A, Essand M, Wechsler-Reya RJ, Falk A, Weishaupt H, Swartling FJ
Citation(s) 31786016
Submission date Nov 09, 2017
Last update date Jan 27, 2020
Contact name Fredrik Johansson Swartling
Organization name Uppsala University
Department Immunology, Genetics and Pathology
Street address Dag Hammarskjölds väg 20
City Uppsala
ZIP/Postal code 752 37
Country Sweden
 
Platforms (1)
GPL21145 Infinium MethylationEPIC
Samples (18)
GSM2849462 A3-41T
GSM2849463 A3-43T
GSM2849464 A3-45T
This SubSeries is part of SuperSeries:
GSE106728 MYCN Drives Disparate Medulloblastoma from Human Embryonic and iPSC-Derived Stem Cells
Relations
BioProject PRJNA417801

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE106727_RAW.tar 416.7 Mb (http)(custom) TAR (of IDAT)
Processed data included within Sample table

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