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Series GSE10748 Query DataSets for GSE10748
Status Public on Mar 08, 2008
Title Expression data from brain tissue of Rattus norvegicus treated with D-Serine
Organism Rattus norvegicus
Experiment type Expression profiling by array
Summary d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored.
Affymetrix microarray technology was used to determine differential gene expression resulting from D-Serine exposure.
Keywords: Dose course
Overall design Male Fisher 344 rats aged 11-12 weeks were treated with various doses (0, 5, 20, 50, 200 & 500 mg/kg) of d-serine and terminally sacrificed 96 hours post-exposure. An approximate 30mg-section of the forebrain was processed for total RNA isolation.
Contributor(s) Chan VT, Davidson ME
Citation(s) 19212759
Submission date Mar 06, 2008
Last update date Jul 31, 2017
Contact name Molly Davidson
Organization name AFRL/RHPB
Street address 2729 R Street, Bldg 837
State/province OH
ZIP/Postal code 45433
Country USA
Platforms (1)
GPL1355 [Rat230_2] Affymetrix Rat Genome 230 2.0 Array
Samples (24)
GSM271362 Exp A, Animal #243, control (0mg/kg) D-Serine
GSM271365 Exp A, Animal #244, control (0mg/kg) D-Serine
GSM271367 Exp A, Animal #245, control (0mg/kg) D-Serine
BioProject PRJNA107529

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE10748_RAW.tar 63.9 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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