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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Dec 21, 2017 |
| Title |
Gene expression analysis to find molecular mechanisms underlying the role of miR-342-5p in HER2 breast cancer |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
The molecular mechanisms behind the miR-342-5p-induced HER2 pathway regulation are not known. Here, we aimed to further investigate the role of miR-342-5p in HER2 driven breast cancer cells. Transfected cells were incubated for 24 hours, and total RNA were run on mRNA arrays.
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| Overall design |
Two HER2 amplified breast cancer cell lines were transiently transfected with miR-342-5p mimic or scrambled negative control miRNA. Transfections were done in three separate biological replicates.
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| Contributor(s) |
Lindholm EM, Leivonen S, Due E, Nebdal D, Børresen-Dale A, Sahlberg KK |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Dec 20, 2017 |
| Last update date |
Jun 14, 2018 |
| Contact name |
Evita Lindholm |
| E-mail(s) |
evilin@rr-research.no
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| Organization name |
Oslo University Hospital, Radiumhospitalet
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| Department |
Genetics
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| Street address |
Ullernchausseen 70
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| City |
Oslo |
| ZIP/Postal code |
0379 |
| Country |
Norway |
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| Platforms (1) |
| GPL17077 |
Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version) |
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| Samples (24)
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| GSM2895366 |
miR-342-5p transfected JIMT-1 cell lines, rep 1 |
| GSM2895367 |
miR-342-5p transfected JIMT-1 cell lines, rep 2 |
| GSM2895368 |
miR-342-5p transfected JIMT-1 cell lines, rep 3 |
| GSM2895369 |
miR-342-5p transfected KPL-4 cell lines, rep 1 |
| GSM2895370 |
miR-342-5p transfected JKPL-4 cell lines, rep 2 |
| GSM2895371 |
miR-342-5p transfected KPL-4 cell lines, rep 3 |
| GSM2895372 |
negative control miRNA transfected JIMT-1 cell lines, rep 1 |
| GSM2895373 |
negative control miRNA transfected JIMT-1 cell lines, rep 2 |
| GSM2895374 |
negative control miRNA transfected JIMT-1 cell lines, rep 3 |
| GSM2895375 |
negative control miRNA transfected KPL-4 cell lines, rep 1 |
| GSM2895376 |
negative control miRNA transfected KPL-4 cell lines, rep 2 |
| GSM2895377 |
negative control miRNA transfected KPL-4 cell lines, rep 3 |
| GSM2895378 |
not transfected JIMT-1 cell lines, rep 1 |
| GSM2895379 |
not transfected JIMT-1 cell lines, rep 2 |
| GSM2895380 |
not transfected JIMT-1 cell lines, rep 3 |
| GSM2895381 |
not transfected KPL-4 cell lines, rep 1 |
| GSM2895382 |
not transfected KPL-4 cell lines, rep 2 |
| GSM2895383 |
not transfected KPL-4 cell lines, rep 3 |
| GSM2895384 |
siERBB2 transfected JIMT-1 cell lines, rep 1 |
| GSM2895385 |
siERBB2 transfected JIMT-1 cell lines, rep 2 |
| GSM2895386 |
siERBB2 transfected JIMT-1 cell lines, rep 3 |
| GSM2895387 |
siERBB2 transfected KPL-4 cell lines, rep 1 |
| GSM2895388 |
siERBB2 transfected KPL-4 cell lines, rep 2 |
| GSM2895389 |
siERBB2 transfected KPL-4 cell lines, rep 3 |
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| Relations |
| BioProject |
PRJNA423163 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE108324_RAW.tar |
268.0 Mb |
(http)(custom) |
TAR (of TXT) |
| GSE108324_raw_data_matrix_24samples.txt.gz |
9.0 Mb |
(ftp)(http) |
TXT |
| Processed data included within Sample table |
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