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| Status |
Public on Jan 09, 2018 |
| Title |
HIV-1 indcued genes in human monocyte-derived macrophages |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
HIV-1 infection of monocyte-derived macrophages does not elicit a detectable type I IFN response in vitro, however, previously published data has shown that blocking STAT1 and STAT3 inhibits HIV-1 replication. Here we test to see if low levels of IFN inducible genes are detectable in human monocyte-derived macrophages that have been infected with HIV-1 in vitro.
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| Overall design |
Monocytes from 5 healthy human donors were differentiated into macrophages in vitro and infected with HIV-1-AD for 7 days. Total RNA was isolated and gene expression was assessed.
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| Contributor(s) |
Taylor JP, Cash MN, Santostefano KE, Nakanishi M, Terada N, Wallet MA |
| Citation(s) |
29437254 |
| NIH grant(s) |
| Grant ID |
Grant title |
Affiliation |
Name |
| R56 AI108434 |
Elimination of persistently HIV-infected cells by targeting host factors |
UNIVERSITY OF FLORIDA |
Mark A Wallet |
| K22 AI095015 |
Novel approach to suppress HIV-1 innate inflammation |
UNIVERSITY OF FLORIDA |
Mark A Wallet |
| R56 AI122813 |
Targeting the host kinase DYRK1A to optimize reversal of HIV-1 latency in CD4 T cells |
UNIVERSITY OF FLORIDA |
Mark A Wallet |
|
| Submission date |
Jan 08, 2018 |
| Last update date |
Feb 18, 2019 |
| Contact name |
Mark A Wallet |
| E-mail(s) |
mawallet@pathology.ufl.edu
|
| Phone |
3522945497
|
| Organization name |
University of Florida
|
| Department |
Pathology
|
| Lab |
Mark Wallet
|
| Street address |
1275 Center Drive
|
| City |
Gainesville |
| State/province |
Florida |
| ZIP/Postal code |
32608 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL5175 |
[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [transcript (gene) version] |
|
| Samples (10)
|
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| Relations |
| BioProject |
PRJNA429041 |
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