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| Status |
Public on Jan 03, 2019 |
| Title |
Clonality analysis in breast tumour pairs using DNA methylation data |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by genome tiling array
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| Summary |
Multiple tumours from the same patient were analysed for DNA methylation to assess tumour clonality. Seventy-four tumours corresponding to 37 patients were stratified into four groups based on the anatomic location of the multiple breast cancers (ipsilateral or bilateral) and time interval between the diagnoses (synchronous or metachronous). Ipsilateral was defined as tumours occurring in the same breast while bilateral was defined as the occurrence of tumours in both breasts. Metachronicity was defined as a time interval greater than six months between the diagnoses of the first and second tumours, while synchronicity specified that the two tumours occurred concurrently (BM: bilateral-metachronous; BS: bilateral-synchronous; IM: ipsilateral-metachronous; IS: ipsilateral-synchronous). A subset of 16 samples was randomly selected to represent each clinical group with four samples corresponding to two patients per group and analysed for DNA methylation using Illumina Infinium Human MethylationEPIC BeadChips.
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| Overall design |
Genomic DNA was isolated from fresh-frozen tissue samples
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| Contributor(s) |
Biermann J, Parris TZ, Nemes S, Danielsson A, Engqvist H, Werner Rönnerman E, Forssell-Aronsson E, Kovács A, Karlsson P, Helou K |
| Citation(s) |
30092821 |
| Submission date |
Jan 10, 2018 |
| Last update date |
Jan 20, 2019 |
| Contact name |
Jana Biermann |
| E-mail(s) |
jana.biermann@gu.se
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| Organization name |
University of Gothenburg
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| Street address |
Medicinaregatan 1F
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| City |
Gothenburg |
| ZIP/Postal code |
413 90 |
| Country |
Sweden |
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| Platforms (1) |
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| Samples (16)
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| This SubSeries is part of SuperSeries: |
| GSE108985 |
Clonal relatedness in tumour pairs of breast cancer patients |
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| Relations |
| BioProject |
PRJNA429346 |
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