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| Status |
Public on Sep 25, 2018 |
| Title |
The Effect of TLR2 Activation on Transcriptome of IFN-induced Microglia |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
In murine glioma models, TLR2 is selectively upregulated in glioma-associated microglia. We found that TLR2 activation led to down-regulation of MHC-II in microglia. Therefore, we examined the effect of TLR2 activation on IFN-gamma-induced microglial transcriptome by in vitro culture of murine adult microglia. In the study, we confirmed that TLR2 activation led to Ciita shutdown and inhibition of MHC-II related genes, which also revealed the role of TLR2 in inducing APC disability and tumor immune escape. In addition, this work can be used to reveal the transcriptional characteristics of murine microglia during IFN-gamma and TLR2 activation.
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| |
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| Overall design |
Examination of transcriptional characteristics in murine adult microglia under TLR2 agonist and IFN-gamma treatments.
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| Web link |
https://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/pubmed/30131377
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| |
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| Contributor(s) |
Qian J, Chu Y |
| Citation(s) |
30131377 |
| Submission date |
Jan 17, 2018 |
| Last update date |
Mar 01, 2019 |
| Contact name |
Jiawen Qian |
| E-mail(s) |
qjw@fudan.edu.cn
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| Organization name |
Fudan University
|
| Department |
Immunology
|
| Lab |
Chu Lab
|
| Street address |
130 Dong'an Road
|
| City |
Shanghai |
| ZIP/Postal code |
200032 |
| Country |
China |
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| Platforms (1) |
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| Samples (11)
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| Relations |
| BioProject |
PRJNA430373 |
| SRA |
SRP131072 |
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