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| Status |
Public on Dec 21, 2018 |
| Title |
In vitro transcription studies used in a proof of concept whole transcriptome model predition study - A673 cells (1 of 4) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
A673 cells were exposed in triplicate to three agrichemicals for 24hrs at 8 concentrations and a DMSO vehicle control (0.001, 0.003, 0.01, 0.03, 0.1, 0.3, 1, 3, and 10 μM plus DMSO vehicle controls). While a common set of DMSO controls was used, these CEL files were RMA normalized independently with each of the chemical treated groups. Gene expression was measured on an Affymetrix GeneTitan system. The compounds used were fenbuconazole (a.k.a FENB, CAS # 114369-43-6) a triazole fungicide, imazalil (a.k.a. IMAZ, CAS # 35554-44-0), an azole pesticide, and 2,4-dichlorophenoxyacetic acid (a.k.a. 2,4-D or 2-4-D in file names, CAS # 94-75-7), a chlorophenoxy herbicide.
CEL files with _Rep2 in their file name indicate arrays that were re-scanned due to technical issues with the initial instrument scan of the GeneTitan peg array.
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| Overall design |
24hr in vitro exposures in triplicate at 9 concentrations - 0.001, 0.003, 0.01, 0.03, 0.1, 0.3, 1, 3, and 10 μM plus DMSO vehicle controls
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| Contributor(s) |
Black MB, Haider S |
| Citation(s) |
30333746 |
| Submission date |
Jan 23, 2018 |
| Last update date |
Dec 23, 2018 |
| Contact name |
Michael B. Black |
| E-mail(s) |
mblack@scitovation.com
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| Phone |
919-354-5223
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| Organization name |
Scitovation, LLC.
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| Street address |
100 Capitola Dr., Suite 106
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| City |
Research Triangle Park |
| State/province |
North Carolina |
| ZIP/Postal code |
27713 |
| Country |
USA |
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| Platforms (1) |
| GPL13158 |
[HT_HG-U133_Plus_PM] Affymetrix HT HG-U133+ PM Array Plate |
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| Samples (90)
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| GSM2944777 |
A673 common DMSO control 1, RMA normalized with FENB samples |
| GSM2944778 |
A673 common DMSO control 2, RMA normalized with FENB samples |
| GSM2944779 |
A673 common DMSO control 3, RMA normalized with FENB samples |
| GSM2944780 |
A673 cells, Fenbuconazole treated at 0.001uM, rep.1 |
| GSM2944781 |
A673 cells, Fenbuconazole treated at 0.001uM, rep.2 |
| GSM2944782 |
A673 cells, Fenbuconazole treated at 0.001uM, rep.3 |
| GSM2944783 |
A673 cells, Fenbuconazole treated at 0.003uM, rep.1 |
| GSM2944784 |
A673 cells, Fenbuconazole treated at 0.003uM, rep.2 |
| GSM2944785 |
A673 cells, Fenbuconazole treated at 0.003uM, rep.3 |
| GSM2944786 |
A673 cells, Fenbuconazole treated at 0.01uM, rep.1 |
| GSM2944787 |
A673 cells, Fenbuconazole treated at 0.01uM, rep.2 |
| GSM2944788 |
A673 cells, Fenbuconazole treated at 0.01uM, rep.3 |
| GSM2944789 |
A673 cells, Fenbuconazole treated at 0.03uM, rep.1 |
| GSM2944790 |
A673 cells, Fenbuconazole treated at 0.03uM, rep.2 |
| GSM2944791 |
A673 cells, Fenbuconazole treated at 0.03uM, rep.3 |
| GSM2944792 |
A673 cells, Fenbuconazole treated at 0.1uM, rep.1 |
| GSM2944793 |
A673 cells, Fenbuconazole treated at 0.1uM, rep.2 |
| GSM2944794 |
A673 cells, Fenbuconazole treated at 0.1uM, rep.3 |
| GSM2944795 |
A673 cells, Fenbuconazole treated at 0.3uM, rep.1 |
| GSM2944796 |
A673 cells, Fenbuconazole treated at 0.3uM, rep.2 |
| GSM2944797 |
A673 cells, Fenbuconazole treated at 0.3uM, rep.3 |
| GSM2944798 |
A673 cells, Fenbuconazole treated at 1uM, rep.1 |
| GSM2944799 |
A673 cells, Fenbuconazole treated at 1uM, rep.2 |
| GSM2944800 |
A673 cells, Fenbuconazole treated at 1uM, rep.3 |
| GSM2944801 |
A673 cells, Fenbuconazole treated at 10uM, rep.1 |
| GSM2944802 |
A673 cells, Fenbuconazole treated at 10uM, rep.2 |
| GSM2944803 |
A673 cells, Fenbuconazole treated at 10uM, rep.3 |
| GSM2944804 |
A673 cells, Fenbuconazole treated at 3uM, rep.1 |
| GSM2944805 |
A673 cells, Fenbuconazole treated at 3uM, rep.2 |
| GSM2944806 |
A673 cells, Fenbuconazole treated at 3uM, rep.3 |
| GSM2944807 |
A673 common DMSO control 1, RMA normalized with IMAZ samples |
| GSM2944808 |
A673 common DMSO control 2, RMA normalized with IMAZ samples |
| GSM2944809 |
A673 common DMSO control 3, RMA normalized with IMAZ samples |
| GSM2944810 |
A673 cells, Imazalil treated at 0.001uM, rep.1 |
| GSM2944811 |
A673 cells, Imazalil treated at 0.001uM, rep.2 |
| GSM2944812 |
A673 cells, Imazalil treated at 0.001uM, rep.3 |
| GSM2944813 |
A673 cells, Imazalil treated at 0.003uM, rep.1 |
| GSM2944814 |
A673 cells, Imazalil treated at 0.003uM, rep.2 |
| GSM2944815 |
A673 cells, Imazalil treated at 0.003uM, rep.3 |
| GSM2944816 |
A673 cells, Imazalil treated at 0.01uM, rep.1 |
| GSM2944817 |
A673 cells, Imazalil treated at 0.01uM, rep.2 |
| GSM2944818 |
A673 cells, Imazalil treated at 0.01uM, rep.3 |
| GSM2944819 |
A673 cells, Imazalil treated at 0.03uM, rep.1 |
| GSM2944820 |
A673 cells, Imazalil treated at 0.03uM, rep.2 |
| GSM2944821 |
A673 cells, Imazalil treated at 0.03uM, rep.3 |
| GSM2944822 |
A673 cells, Imazalil treated at 0.1uM, rep.1 |
| GSM2944823 |
A673 cells, Imazalil treated at 0.1uM, rep.2 |
| GSM2944824 |
A673 cells, Imazalil treated at 0.1uM, rep.3 |
| GSM2944825 |
A673 cells, Imazalil treated at 0.3uM, rep.1 |
| GSM2944826 |
A673 cells, Imazalil treated at 0.3uM, rep.2 |
| GSM2944827 |
A673 cells, Imazalil treated at 0.3uM, rep.3 |
| GSM2944828 |
A673 cells, Imazalil treated at 1uM, rep.1 |
| GSM2944829 |
A673 cells, Imazalil treated at 1uM, rep.2 |
| GSM2944830 |
A673 cells, Imazalil treated at 1uM, rep.3 |
| GSM2944831 |
A673 cells, Imazalil treated at 10uM, rep.1 |
| GSM2944832 |
A673 cells, Imazalil treated at 10uM, rep.2 |
| GSM2944833 |
A673 cells, Imazalil treated at 10uM, rep.3 |
| GSM2944834 |
A673 cells, Imazalil treated at 3uM, rep.1 |
| GSM2944835 |
A673 cells, Imazalil treated at 3uM, rep.2 |
| GSM2944836 |
A673 cells, Imazalil treated at 3uM, rep.3 |
| GSM2944837 |
A673 common DMSO control 1, RMA normalized with 2-4-D samples |
| GSM2944838 |
A673 common DMSO control 2, RMA normalized with 2-4-D samples |
| GSM2944839 |
A673 common DMSO control 3, RMA normalized with 2-4-D samples |
| GSM2944840 |
A673 cells, 2,4-D treated at 0.001uM, rep.1 |
| GSM2944841 |
A673 cells, 2,4-D treated at 0.001uM, rep.2 |
| GSM2944842 |
A673 cells, 2,4-D treated at 0.001uM, rep.3 |
| GSM2944843 |
A673 cells, 2,4-D treated at 0.003uM, rep.1 |
| GSM2944844 |
A673 cells, 2,4-D treated at 0.003uM, rep.2 |
| GSM2944845 |
A673 cells, 2,4-D treated at 0.003uM, rep.3 |
| GSM2944846 |
A673 cells, 2,4-D treated at 0.01uM, rep.1 |
| GSM2944847 |
A673 cells, 2,4-D treated at 0.01uM, rep.2 |
| GSM2944848 |
A673 cells, 2,4-D treated at 0.01uM, rep.3 |
| GSM2944849 |
A673 cells, 2,4-D treated at 0.03uM, rep.1 |
| GSM2944850 |
A673 cells, 2,4-D treated at 0.03uM, rep.2 |
| GSM2944851 |
A673 cells, 2,4-D treated at 0.03uM, rep.3 |
| GSM2944852 |
A673 cells, 2,4-D treated at 0.1uM, rep.1 |
| GSM2944853 |
A673 cells, 2,4-D treated at 0.1uM, rep.2 |
| GSM2944854 |
A673 cells, 2,4-D treated at 0.1uM, rep.3 |
| GSM2944855 |
A673 cells, 2,4-D treated at 0.3uM, rep.1 |
| GSM2944856 |
A673 cells, 2,4-D treated at 0.3uM, rep.2 |
| GSM2944857 |
A673 cells, 2,4-D treated at 0.3uM, rep.3 |
| GSM2944858 |
A673 cells, 2,4-D treated at 1uM, rep.1 |
| GSM2944859 |
A673 cells, 2,4-D treated at 1uM, rep.2 |
| GSM2944860 |
A673 cells, 2,4-D treated at 1uM, rep.3 |
| GSM2944861 |
A673 cells, 2,4-D treated at 10uM, rep.1 |
| GSM2944862 |
A673 cells, 2,4-D treated at 10uM, rep.2 |
| GSM2944863 |
A673 cells, 2,4-D treated at 10uM, rep.3 |
| GSM2944864 |
A673 cells, 2,4-D treated at 3uM, rep.1 |
| GSM2944865 |
A673 cells, 2,4-D treated at 3uM, rep.2 |
| GSM2944866 |
A673 cells, 2,4-D treated at 3uM, rep.3 |
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| This SubSeries is part of SuperSeries: |
| GSE109514 |
In vitro transcription studies used in a proof of concept whole transcriptome model predition study |
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| Relations |
| BioProject |
PRJNA431288 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE109508_RAW.tar |
185.2 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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