|
| Status |
Public on Feb 15, 2018 |
| Title |
PTEN Deficiency Promotes Pathological Vascular Remodeling of Human Coronary Arteries |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
|
| Summary |
Gene expression profiles of Rat aortic smooth muscle clonal isolates of PTEN knock-down and control wild-type.
We used Affymetrix microarrays to detail the global program of gene expression changes between PTEN deficient and wild type smooth muscle cells. We identified distinct classes of up- and down-regulated genes during this process.
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| Overall design |
Infection of Rat VSMC's with retroviral shRNA specific to PTEN or non-targeting control in order to compare the gene expression under basal, low serum, conditions.
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| |
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| Contributor(s) |
Weiser-Evans M, Moulton K |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Feb 14, 2018 |
| Last update date |
Feb 15, 2018 |
| Contact name |
Mary Weiser-Evans |
| E-mail(s) |
mary.weiser@ucdenver.edu
|
| Organization name |
University of Colorado Denver
|
| Department |
Department of Renal Medicine and Hypertension
|
| Lab |
Weiser-Evans
|
| Street address |
12700 East 19th Ave
|
| City |
Aurora |
| State/province |
Colorado |
| ZIP/Postal code |
80034 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL6247 |
[RaGene-1_0-st] Affymetrix Rat Gene 1.0 ST Array [transcript (gene) version] |
|
| Samples (4)
|
| GSM3004384 |
VSMC clonal isolate wild type, biological rep1 |
| GSM3004385 |
VSMC clonal isolate wild type, biological rep2 |
| GSM3004386 |
VSMC clonal isolate PTEN knock down , biological rep1 |
| GSM3004387 |
VSMC clonal isolate PTEN knock down , biological rep2 |
|
| Relations |
| BioProject |
PRJNA434117 |
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