|
| Status |
Public on Dec 31, 2019 |
| Title |
Whole kidneys at embryonic day 16.5: wildtype (WT) vs. conditional Dot1-knockout (KO) from Six2-positive nephron progenitor cells (NPC) |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Transcriptional profiling of whole kidneys from Six2CreEGFP mice without (WT) or with (KO) homozygously floxed DOT1 alleles at the age of embryonic day 16.5. This experiment aimed to uncover the genome-wide alternation in gene expression resulting from the removal of DOT1 gene in the nephron progenitor population (Six2 positive) and successive changes to the series of events in kidney development.
|
| |
|
| Overall design |
Two-condition experiment, WT vs. KO kidneys. Biological replicates: 4 WTs and 4 KOs.
|
| |
|
| Contributor(s) |
Li Y, Wang F, El-Dahr S |
| Citation(s) |
33315499 |
| Submission date |
Feb 21, 2018 |
| Last update date |
Feb 08, 2022 |
| Contact name |
Samir S El-Dahr |
| E-mail(s) |
seldahr@tulane.edu
|
| Organization name |
Tulane University School of Medicine
|
| Department |
Pediatrics
|
| Lab |
Dr. El-Dahr
|
| Street address |
1430 Tulane Ave
|
| City |
New Orleans |
| State/province |
LA |
| ZIP/Postal code |
70112 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL13912 |
Agilent-028005 SurePrint G3 Mouse GE 8x60K Microarray (Feature Number version) |
|
| Samples (8)
|
| GSM3019017 |
Control wildtype Kidney Pair 4 |
| GSM3019018 |
Sample Kidney Pair 1 with DOT1-knockout NPC |
| GSM3019019 |
Sample Kidney Pair 2 with DOT1-knockout NPC |
| GSM3019020 |
Sample Kidney Pair 3 with DOT1-knockout NPC |
| GSM3019021 |
Sample Kidney Pair 4 with DOT1-knockout NPC |
|
| Relations |
| BioProject |
PRJNA434822 |
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