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| Status |
Public on Apr 09, 2008 |
| Title |
Wildtype, Fah and Fah, p21 ON and OFF NTBC |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Fumarylacetoacetate hydrolase (Fah), the last enzyme of the tyrosine degradation pathway, is specifically expressed in hepatocytes in the liver. Loss of Fah leads to liver failure in mice within 6-8 weeks. This can be prevented by blocking tyrosine degradation upstream of Fah with 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione (NTBC). Here, we investigate the impact of p21 on global gene expression in Fah deficiency.
Keywords: treatment, genotype
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| Overall design |
Livers from adult wildtype, Fah or Fah, p21 knockout mice were analyzed either after continuous treatment (ON) with NTBC or after NTBC withdrawal for 14 days (OFF).
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| Contributor(s) |
Willenbring H, Grompe M |
| Citation(s) |
18598944 |
| Submission date |
Apr 08, 2008 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Holger Willenbring |
| E-mail(s) |
willenbringh@stemcell.ucsf.edu
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| Organization name |
UCSF
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| Street address |
35 Medical Center Way
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| City |
San Francisco |
| State/province |
CA |
| ZIP/Postal code |
94143 |
| Country |
USA |
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| Platforms (2) |
| GPL339 |
[MOE430A] Affymetrix Mouse Expression 430A Array |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA106977 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE11098_RAW.tar |
95.2 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
| Processed data included within Sample table |
| Processed data provided as supplementary file |
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