 |
 |
GEO help: Mouse over screen elements for information. |
|
| Status |
Public on Feb 24, 2018 |
| Title |
Gene expression of cardiac fibroblasts post-MI |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Cardiac fibroblasts stay relatively quiescent under normal condition. These cells differentiate to myofibroblasts after myocardial infarction (MI), characterized by the expression of contractile proteins and secretion of elevated levels of extracellular matrix proteins, leading to cardiac remodeling. The differentiated myofiroblasts gradually lose most myofibroblast phenotypes but still persist in the infarct area to maintain the tissue structural integrity.
We used microarrays to reveal the change in cardiac fibroblast gene expression profile after MI.
|
| |
|
| Overall design |
TCF21 lineage-traced cardiac fibroblasts were isolated from left ventricle by FACS before, and 3 days, 7 days, 2 weeks, and 4 weeks post-MI for RNA extraction and Affymetrix microarrays.
|
| |
|
| Contributor(s) |
Fu X, Prasad V, Molkentin J |
| Citation(s) |
29664017 |
| Submission date |
Feb 23, 2018 |
| Last update date |
Feb 01, 2019 |
| Contact name |
Vikram Prasad |
| Organization name |
Cincinnati Children's Hospital Medical Center
|
| Department |
Molecular Cardiovascular Biology
|
| Street address |
240, Albert Sabin Way
|
| City |
Cincinnati |
| State/province |
OH |
| ZIP/Postal code |
45229 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL23038 |
[Clariom_S_Mouse] Affymetrix Clariom S Assay, Mouse (Includes Pico Assay) |
|
| Samples (14)
|
| GSM3021173 |
CF 3D post-MI, biological rep1 |
| GSM3021174 |
CF 3D post-MI, biological rep2 |
| GSM3021175 |
CF 3D post-MI, biological rep3 |
| GSM3021176 |
CF 7D post-MI, biological rep1 |
| GSM3021177 |
CF 7D post-MI, biological rep2 |
| GSM3021178 |
CF 7D post-MI, biological rep3 |
| GSM3021179 |
CF 2W post-MI, biological rep1 |
| GSM3021180 |
CF 2W post-MI, biological rep2 |
| GSM3021181 |
CF 4W post-MI, biological rep1 |
| GSM3021182 |
CF 4W post-MI, biological rep2 |
| GSM3021183 |
CF 4W post-MI, biological rep3 |
|
| Relations |
| BioProject |
PRJNA435730 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE111059_RAW.tar |
15.8 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
|
|
|
|
 |
Less...
More...