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| Status |
Public on Mar 04, 2019 |
| Title |
Effect of Polybrominated diphenyl ethers (PBDEs) on gene expression of MCF7 cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
RNA sequence analysis showed that PBDE47 had estrogenic activity through cell cycle regulation, and PBDE100 and PBDE153 had anti-estrogenic activity throguth ER and AhR cross talk.
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| Overall design |
MCF7 expression was compared with control (DMSO, dimethyl sulfoxide), a known estrogen agonist (PPT, propyl pyrazole), a combination of PPT and MPP (methyl piperidino pyrazole, a known estrogen antagonist to counteract the effect of PPT treatment), and 3 types of PBDEs. PBDE47 was treated without any other compounds (with the expectation that it is an estrogen agonist), while PBDE100 and PBDE153 were treated along with PPT (so that expected estrogen antagonists could counteract the PPT treatment).
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| |
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| Contributor(s) |
Kanaya N, Chen S |
| Citation(s) |
30796839 |
| Submission date |
Feb 27, 2018 |
| Last update date |
Mar 27, 2019 |
| Contact name |
Noriko Kanaya |
| E-mail(s) |
kana-nori@hotmail.co.jp
|
| Organization name |
Beckman Research Institute at City of Hope
|
| Department |
Cancer Biology
|
| Street address |
1500 East Duarte
|
| City |
Duarte |
| ZIP/Postal code |
91010 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
|
| Samples (18)
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| This SubSeries is part of SuperSeries: |
| GSE119588 |
Polybrominated diphenyl ethers (PBDEs) |
|
| Relations |
| BioProject |
PRJNA436154 |
| SRA |
SRP133598 |
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