|
| Status |
Public on Mar 01, 2018 |
| Title |
Astrocyte mRNA expression - comparison of wild type animals to CETP transgenic animals |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
CETP transfers lipids and cholesteryl esters between lipoproteins. This leads to elevated LDL-cholesterol levels. We found elevated cholesterol levels in the brains CETP transgenic animals. We wanted to test whether this is due to increased cholesterol synthesis by astrocytes
2 animals that were genotyped as wild type showed CETP transcription in our RT-qPCR (WT_1 & WT_5) and were excluded
|
| |
|
| Overall design |
purified astrocytes from wild type animals on a standard mouse diet are compared to astrocytes from CETP tansgenic animals on a 1% cholesterol diet (dietary cholesterol induced CETP expression)
|
| |
|
| Contributor(s) |
Oestereich F, Munter L |
| Citation(s) |
35921880 |
| Submission date |
Feb 28, 2018 |
| Last update date |
Sep 27, 2022 |
| Contact name |
Lisa Marie Munter |
| E-mail(s) |
lisa.munter@mcgill.ca
|
| Organization name |
McGill University
|
| Department |
Pharmacology
|
| Lab |
Munter lab
|
| Street address |
3649 Prom. Sir-William-Osler
|
| City |
Montreal |
| State/province |
Quebec |
| ZIP/Postal code |
H3G 0B1 |
| Country |
Canada |
| |
|
| Platforms (1) |
| GPL23038 |
[Clariom_S_Mouse] Affymetrix Clariom S Assay, Mouse (Includes Pico Assay) |
|
| Samples (7)
|
|
| Relations |
| BioProject |
PRJNA436339 |
Less...
More...