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Series GSE111640 Query DataSets for GSE111640
Status Public on Jul 26, 2019
Title Deletion of Lats 1 and 2 in mouse pancreatic acinar cells
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Mice with adult pancreatic acinar cell–specific deletion of Lats1&2 genes by using CreER/LoxP were generated. Pancreata were collected and profiled using RNA-seq. The RNA-sequencing data identified upregulation of pro-inflammatory and pro-fibrotic genes in Lats1&2 null pancreata, which may play important roles in stimulating PSC activation and promoting pancreatic fibrosis.
 
Overall design 6-12 week old mice with Lats 1 & 2 double knockout (PL) were used in the study
 
Contributor(s) Gao M, Liu J, Nipper M, Chen Y, Wang P
Citation(s) 31513574
Submission date Mar 09, 2018
Last update date Sep 20, 2019
Contact name Yidong Chen
E-mail(s) cheny8@uthscsa.edu
Phone 2105629163
Organization name UT Health Science Center at San Antonio
Department Population Health Sciences
Street address 8403 Floyd Curl Drive, MSC 7784
City San Antonio
State/province Texas
ZIP/Postal code 78229
Country USA
 
Platforms (1)
GPL21493 Illumina HiSeq 3000 (Mus musculus)
Samples (16)
GSM3036215 Control-1
GSM3036216 Control-2
GSM3036217 Control-3
Relations
BioProject PRJNA437647
SRA SRP134375

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE111640_RAW.tar 1.4 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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