|
| Status |
Public on Aug 28, 2018 |
| Title |
Role of SmcHD1 in the establishment of the epigenetic states required for the maintenance of X chromosome inactivation [ChIP-seq] |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
It has been shown that functional deficiency of SmcHD1, a noncanonical member of SMC family proteins, results in derepression of X-inactivated genes in postimplantation female mouse embryos. In this study, we found that derepression of X-inactivated genes accompanied a local reduction in the enrichment of H3K27me3 in mouse embryonic fibroblasts (MEFs) prepared from female fetuses deficient for SmcHD1.
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| |
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| Overall design |
ChIP-seq analysis of mouse embryonic fibroblasts (MEFs) prepared from female fetuses deficient for SmcHD1
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| |
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| Contributor(s) |
Sakakibara Y, Nagao K, Obuse C, Sado T |
| Citation(s) |
30126901 |
| Submission date |
Mar 20, 2018 |
| Last update date |
Aug 28, 2018 |
| Contact name |
Koji Nagao |
| E-mail(s) |
nagao@bio.sci.osaka-u.ac.jp
|
| Organization name |
Osaka University
|
| Department |
Graduate School of Science
|
| Lab |
Obuse Lab.
|
| Street address |
1-1 Machikaneyama
|
| City |
Toyonaka |
| State/province |
Osaka |
| ZIP/Postal code |
560 0043 |
| Country |
Japan |
| |
|
| Platforms (1) |
| GPL11002 |
Illumina Genome Analyzer IIx (Mus musculus) |
|
| Samples (4)
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| This SubSeries is part of SuperSeries: |
| GSE112097 |
Role of SmcHD1 in the establishment of the epigenetic states required for the maintenance of X chromosome inactivation |
|
| Relations |
| BioProject |
PRJNA439361 |
| SRA |
SRP136199 |
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