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Status |
Public on Apr 11, 2019 |
Title |
Impact of Dnm3os silencing on bleomycin-induced lung fibrosis |
Organism |
Mus musculus |
Experiment type |
Expression profiling by array
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Summary |
To assess the impact of Dnm3os silencing on lung fibrogenesis, anti-Dnm3os gapmers (5mg/kg, 2 distinct designs: GP DNM3OS-1 and GP DNM3OS-3) or control gapmer (5mg/kg, GP Ctrl) formulated for in vivo delivery was instilled intratracheally 4 days and 2 days before intratracheal administration of bleomycin (1 unit/kg) or PBS as well as 4 days after bleomycin or PBS treatment.
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Overall design |
Experiments were performed in a one color design, corresponding to 6 conditions (GP Ctrl + PBS n = 3, GP DNM3OS-1 + PBS n = 3, GP DNM3OS-3 + PBS n = 3, GP Ctrl + Bleo n = 5, GP DNM3OS-1 + Bleo n = 5, GP DNM3OS-3 + Bleo n = 5) for a total of 24 samples.
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Web link |
http://www.genomique.info:8080/merge/index
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Contributor(s) |
Savary G, Nottet N, Pottier N, Mari B, Barbry P, Lebrigand K |
Citation(s) |
30964696 |
Submission date |
Apr 06, 2018 |
Last update date |
Mar 31, 2020 |
Contact name |
Kevin Lebrigand |
Organization name |
IPMC/CNRS
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Lab |
Functional Genomics Platform of Nice-Sophia-Antipolis, France.
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Street address |
660 route des lucioles
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City |
Valbonne - Sophia-Antipolis |
ZIP/Postal code |
06560 |
Country |
France |
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Platforms (1) |
GPL13912 |
Agilent-028005 SurePrint G3 Mouse GE 8x60K Microarray (Feature Number version) |
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Samples (24)
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This SubSeries is part of SuperSeries: |
GSE97834 |
The DNM3OS lncRNA is a reservoir of fibromiRs with major functions in fibroblast response to TGF-beta and fibrogenesis |
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Relations |
BioProject |
PRJNA449099 |