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| Status |
Public on Sep 27, 2018 |
| Title |
RNA-seq analysis of hearts from control and cardiomyocyte-specific PRMT1-deficient mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We found that cardiomyocyte-specific PRMT1-deficient (PRMT1-cKO) mice showed dilated cardiomyopathy and aberrant cardiac alternative splicing. To identify novel cardiac splicing events, we performed a comprehensive analysis of gene expression changes in hearts of wildtype (WT) and PRMT1-cKO mice using RNA sequencing (RNA-Seq). To investigate differentially expressed genes (false discovery rate (FDR) p<0.05, fold change >2) between control and PRMT1-cKO mice, we performed pairwise comparisons of RNA-Seq data using the CLC Genomics Workbench software.
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| Overall design |
Examination of mRNA profile and alternative splicing in control and PRMT1-cKO mice (n=2).
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| Contributor(s) |
Murata K, Kim JD, Fukamizu A |
| Citation(s) |
30321814 |
| Submission date |
Apr 10, 2018 |
| Last update date |
Oct 25, 2018 |
| Contact name |
Jun-Dal Kim |
| Organization name |
University of Toyama
|
| Department |
Department of Complex Biosystem Research (CBR), Institute of National Medicine (INM)
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| Lab |
Complex Biosystem Research Lab.
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| Street address |
2630 Sugitani
|
| City |
Toyama |
| State/province |
Toyama |
| ZIP/Postal code |
930-0194 |
| Country |
Japan |
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| Platforms (1) |
| GPL15907 |
AB 5500xl Genetic Analyzer (Mus musculus) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA449535 |
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