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| Status |
Public on Aug 07, 2018 |
| Title |
Expression data after PAK2 knockdown in head and neck cancer cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Epigenetic mechanisms play an important role in the cellular development and maintenance of cellular homeostasis. Any alteration of epigenetic mechanisms via the changes in DNA methylation and histone modification may lead to various diseases including cancer. The differential expression of histone modifiers has been observed in various malignancies.
We used microarray to detail the differential gene-expression pattern of head and neck (HNC) cancer cells upon depletion of p21 activated kinase (PAK2). we identified distinct class of downregulated genes, majorly associated with cellular proliferation and tumorigenesis.
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| Overall design |
In this study, we have analyzed the global expression pattern upon PAK2 depletion compared to shControl cells using Affymetrix Human Transcriptome 2.0 platform. Array data was processed by Transcriptome Analysis Console (TAC). The experiment was performed with biological replicates.
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| Web link |
https://www.nature.com/articles/s41419-018-0887-0
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| Contributor(s) |
Gupta A, Ajith A, Singh S, Panday RK, Samaiya A, Shukla S |
| Citation(s) |
30068946 |
| Submission date |
Apr 18, 2018 |
| Last update date |
Oct 29, 2018 |
| Contact name |
Sanjeev Shukla |
| E-mail(s) |
sanjeevs@iiserb.ac.in
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| Phone |
9584635471
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| Organization name |
Indian Institute of Science Education and Research Bhopal
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| Department |
Biological Sciences
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| Lab |
Epigenetics and RNA Processing Lab (ERPL)
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| Street address |
Bhopal Bypass Road, Bhauri Bhopal 462 066 Madhya Pradesh, INDIA
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| City |
Bhopal |
| State/province |
Madhya Prades |
| ZIP/Postal code |
462066 |
| Country |
India |
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| Platforms (1) |
| GPL17586 |
[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version] |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA450818 |
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