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| Status |
Public on May 01, 2018 |
| Title |
Impact of Lmo2 expression on cell lineage decision during T-cell leukemogenesis [RNA-seq] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The goal of this study is compare the transcriptome profilling of different genetically engineered mouse models to the Human scenerio, in order to better understand the role of Lmo2 expression on cell lineage decision during T-cell leukemogenesis.
Results: The up-regulated Rosa26-Lmo2+Sca1-Cre and Sca1-Lmo2 signatures shows a significant enrichment in the human T-ALL group.
Conclusion: The similarity between Rosa26-Lmo2+Sca1-Cre and Human T-ALL signature is in accordance to the Human T-ALL situation wherein the expression of LMO2 is present throughout in tumor cells.
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| Overall design |
14 samples were analyzed representing different mouse model employed in the study, including 4 control samples obtained from healthy thymus.
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| Contributor(s) |
García-Ramírez I, Bhatia S, Rodríguez-Hernández G, González-Herrero I, Walter C, González de Tena-Dávila S, Parvin S, Haas O, Woessmann W, Stanulla M, Schrappe M, Dugas M, Natkunam Y, Orfao A, Domínguez V, Pintado B, Blanco O, Alonso-López D, De Las Rivas J, Martín-Lorenzo A, Jiménez R, García Criado FJ, García Cenador MB, Lossos IS, Vicente-Dueñas C, Borkhardt A, Hauer J, Sánchez-García I |
| Citation(s) |
29880602 |
| Submission date |
Apr 30, 2018 |
| Last update date |
May 18, 2019 |
| Contact name |
Isidro Sánchez García |
| E-mail(s) |
isg@usal.es
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| Organization name |
Inst. de Inv. Biomédica de Salamanca (IBSAL). H. U. de Salamanca. Inst. de Biología Molecular y Celular del Cáncer (IBMCC).
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| Department |
Centro de inv. del Cáncer (CIC).
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| Street address |
Campus Miguel de Unamuno
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| City |
Salamanca |
| ZIP/Postal code |
E37007 |
| Country |
Spain |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (14)
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| This SubSeries is part of SuperSeries: |
| GSE83572 |
LMO2 expression in HSCs causes T-ALL in the presence of an intact thymic niche |
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| Relations |
| BioProject |
PRJNA454297 |
| SRA |
SRP144047 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE113864_rawCounts.xls.gz |
2.5 Mb |
(ftp)(http) |
XLS |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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