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Series GSE114020 Query DataSets for GSE114020
Status Public on Jun 21, 2018
Title Effect of Notch Signaling Inhibitor on Gene Expression in Lipopolysaccharide-stimulated Macrophages in the Presence of Immune Complex
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Lipopolysaccharide (LPS)/immunue complex (IC) stimulated macrophages produce cytokine profiles that differe from LPS-stimulated inflammatory macropahges. Notch signaling is activated in LPS/IC-stimulated macrophages and inhibition of Notch signaling reduced IL-10 production. This study investigated the effect of gamma-secretase inhibitor (GSI) that suppresses Notch signaling pathway, on gene expression profiles in macrophages activated by LPS/IC.
Overall design Gamma secretase inhibitor (GSI)-treated bone marrow derived macrophage mRNA profiles were generated by deep sequencing using Illumina NextSeq 500. The results were compared between vehicle control (dimethylsulfoxide)-treated cells and GSI-treated cells.
Contributor(s) Kongkavitoon P, Palaga T, Tangtanatakul P, Wongchana W, Prombutara P
Citation(s) 29889863
Submission date May 03, 2018
Last update date Mar 25, 2019
Contact name Tanapat Palaga
Phone 6622185070
Organization name Chulalongkorn University
Department Microbiology
Lab 2015
Street address Payathai Road, Pathumwan
City Bangkok
ZIP/Postal code 10330
Country Thailand
Platforms (1)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (16)
GSM3130805 LPS_IC_DMSO_REP1_001
GSM3130806 LPS_IC_DMSO_REP1_002
GSM3130807 LPS_IC_DMSO_REP1_003
BioProject PRJNA454891
SRA SRP144516

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Supplementary file Size Download File type/resource
GSE114020_rawcount.txt.gz 949.7 Kb (ftp)(http) TXT
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