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Series GSE114020 Query DataSets for GSE114020
Status Public on Jun 21, 2018
Title Effect of Notch Signaling Inhibitor on Gene Expression in Lipopolysaccharide-stimulated Macrophages in the Presence of Immune Complex
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Lipopolysaccharide (LPS)/immunue complex (IC) stimulated macrophages produce cytokine profiles that differe from LPS-stimulated inflammatory macropahges. Notch signaling is activated in LPS/IC-stimulated macrophages and inhibition of Notch signaling reduced IL-10 production. This study investigated the effect of gamma-secretase inhibitor (GSI) that suppresses Notch signaling pathway, on gene expression profiles in macrophages activated by LPS/IC.
 
Overall design Gamma secretase inhibitor (GSI)-treated bone marrow derived macrophage mRNA profiles were generated by deep sequencing using Illumina NextSeq 500. The results were compared between vehicle control (dimethylsulfoxide)-treated cells and GSI-treated cells.
 
Contributor(s) Kongkavitoon P, Palaga T, Tangtanatakul P, Wongchana W, Prombutara P
Citation(s) 29889863
Submission date May 03, 2018
Last update date Mar 25, 2019
Contact name Tanapat Palaga
E-mail(s) tanapat.p@chula.ac.th
Phone 6622185070
Organization name Chulalongkorn University
Department Microbiology
Lab 2015
Street address Payathai Road, Pathumwan
City Bangkok
ZIP/Postal code 10330
Country Thailand
 
Platforms (1)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (16)
GSM3130805 LPS_IC_DMSO_REP1_001
GSM3130806 LPS_IC_DMSO_REP1_002
GSM3130807 LPS_IC_DMSO_REP1_003
Relations
BioProject PRJNA454891
SRA SRP144516

Download family Format
SOFT formatted family file(s) SOFTHelp
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Supplementary file Size Download File type/resource
GSE114020_rawcount.txt.gz 949.7 Kb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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