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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Mar 24, 2004 |
| Title |
Insulin-like growth factor 1 (IGF1) heart study |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
IGF1 and IGF1 receptors (IGF1R) are present in the adult heart and have been shown to be essential for myocardial performance. Insulin-like growth factor 1 (IGF1) is produced in numerous tissues particularly by the liver in response to growth hormone stimulation and is an important factor in the regulation of post-natal growth and development. We have generated and characterized transgenic mice over-expressing the IGF1R. We crossed IGF1R transgenic mice with dominant negative (dn)PI3K (p110) and with constitutively active (ca)PI3K(p110) transgenic mice. Expression profiling was performed on the ventricles of IGF1R, IGF1R-caPI3K, IGF1R-dnPI3K, caPI3K, dnPI3K transgenic female mice at 3 months of age. Non-transgenic littermates were used as controls.
Keywords = http://cardiogenomics.med.harvard.edu/groups/proj1/pages/igfr1_home.html
Keywords: other
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| Contributor(s) |
McMullen J, Shioi T, Huang W, Zhang L, Tarnavski O, Bisping E, Schinke M, Kong S, Sherwood MC, Brown J, Riggi LE, Kang PM, Izumo S |
| Citation(s) |
14597618 |
| Submission date |
Mar 24, 2004 |
| Last update date |
Feb 18, 2018 |
| Contact name |
Martina Schinke |
| URL |
http://www.cardiogenomics.org
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| Organization name |
Harvard University
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| Department |
Bauer Center for Genomic Research
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| Lab |
Cardiogenomics
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| Street address |
7 Divinity Ave
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| City |
Cambridge |
| State/province |
MA |
| ZIP/Postal code |
02138 |
| Country |
USA |
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| Platforms (1) |
| GPL81 |
[MG_U74Av2] Affymetrix Murine Genome U74A Version 2 Array |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA87265 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE1143_RAW.tar |
25.1 Mb |
(http)(custom) |
TAR (of CEL) |
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