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| Status |
Public on Mar 19, 2019 |
| Title |
Autocrine Motility Factor Modulates Proliferation Signaling Mediated By GPER |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Traditional surgery plus radiotherapy or chemotherapy, existing targeted therapies failed to significantly improve the survival rate of recurrent endometrial cancer, so suggesting that mechanism of recurrence and progression that modulates in endometrial cancer is clinically important. Here, we show that GPER(G protein-coupled estrogen receptor 1) was binded to AMF, and the complex were translocation form plasma to cytoplasmic. Mechanistic investigations elucidated that interaction of AMF with GPER triggers phosphoinositide-3-kinase (PI3K) signaling activating and accelerating the ability of endometrial cancer cells growth. Furthermore, we found that AMF may contribute to GPER-mediated endometrial cancer progression using animal experiments and human histological experiments which be consistent with the above conclusions. On the basis of these evidences including invivo and invitro, our findings suggest that AMF–GPER interaction might be novel key molecular targets for therapeutic management of patients with endometrial cancer, whose disease were progression and recurrence.
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| Overall design |
endometrial cancer was used in this experiment and data analysis of the 4 samples have been completed.spec-2/shAMFR VS spec-2, Ishikawa/shAMFR VS Ishikawa
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| Contributor(s) |
li y, wan x |
| Citation(s) |
30836961 |
| Submission date |
May 11, 2018 |
| Last update date |
Mar 19, 2019 |
| Contact name |
yiran li |
| E-mail(s) |
yiran_eric@126.com
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| Phone |
15216688183
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| Organization name |
Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China
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| Street address |
Gaoke West Road 2699
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| City |
shanghai |
| ZIP/Postal code |
201204 |
| Country |
China |
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| Platforms (1) |
| GPL17077 |
Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA471076 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE114362_RAW.tar |
49.5 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
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