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Series GSE11493 Query DataSets for GSE11493
Status Public on May 19, 2008
Title Comparison of transcripts in zebrafish tumors
Organism Danio rerio
Experiment type Expression profiling by array
Summary The goal of this experiment was to compare the genes expressed in malignant peripheral nerve sheath tumors (MPNSTs) that arise in zebrafish as a result of homozygous mutation of the p53 gene or heterozygous mutation of several different ribosomal protein (rp) mutations. Since MPNSTs arise very rarely in wild type zebrafish, it seemed a possibility that p53 and rps may in fact be functioning in similar pathways. The tumors arising from the different mutations had been previously classified as similar by histology, thus the goal of the array experiments was to establish if any molecular signatures could be found that could delineate the p53 from the rp MPNSTs.

Keywords: Zebrafish malignant peripheral nerve sheath tumors from different genetic backgrounds
 
Overall design The mRNAs from 6 different MPNSTs arising from rp mutations (3 from rpL35, 1 from rpL14, 1 from rpS5, 1 from rpS11) were compared to mRNA from 3 MPNSTs arising from the p53 M214K/M214K mutation. These were also compared to the mRNA from 2 spontaneously forming seminoma tumors from random genetic backgrounds.
 
Contributor(s) MacInnes A, Amsterdam A, Whittaker CA, Lees JA, Hopkins N
Citation(s) 18641120
Submission date May 19, 2008
Last update date Jan 25, 2018
Contact name Charles Arthur Whittaker
E-mail(s) charliew@mit.edu
Organization name Koch Institute
Street address 77 Mass Ave 76-189
City Cambridge
State/province MA
ZIP/Postal code 02152
Country USA
 
Platforms (1)
GPL1319 [Zebrafish] Affymetrix Zebrafish Genome Array
Samples (11)
GSM289389 rpL35 +/- MPNST_54
GSM289390 rpL35 +/- MPNST_55
GSM289391 rpL35 +/- MPNST_56
Relations
BioProject PRJNA106307

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Supplementary file Size Download File type/resource
GSE11493_RAW.tar 37.8 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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