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| Status |
Public on May 28, 2020 |
| Title |
Translational regulation of RANKL by CPEB2 regulates mammary gland development and luminal tumorigenesis (Affymetrix Microarrays) |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Here we show that the RNA-binding protein CPEB2 controls synthesis of RANKL, thereby modulating epithealial proliferation, differentiation and breast cancer outcome
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| Overall design |
Mouse array in duplicates of freshly sorted mammary epithelial populations: myoepithelial (Epcam_low and CD49f_high) and luminal (Epcam_high and CD49f_low). The sorted luminal subpopulations were non-clonogenic luminal (Sca1+CD49b-), ductal progenitors (Sca1+CD49b+) and alveolar progenitors (Sca1-Cd49b+).
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| Contributor(s) |
Rosa P, Raul M |
| Citation(s) |
32440535 |
| Submission date |
May 31, 2018 |
| Last update date |
May 28, 2020 |
| Contact name |
Oscar Reina Garcia |
| E-mail(s) |
oscar.reina@irbbarcelona.org
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| Organization name |
IRB Barcelona
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| Department |
Biostatistics and Bioinformatics
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| Street address |
C/Baldiri Reixac 10
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| City |
Barcelona |
| State/province |
Barcelona |
| ZIP/Postal code |
08028 |
| Country |
Spain |
| |
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| Platforms (1) |
| GPL11180 |
[HT_MG-430_PM] Affymetrix HT MG-430 PM Array Plate |
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| Samples (16)
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| This SubSeries is part of SuperSeries: |
| GSE115175 |
Translational regulation of RANKL by CPEB2 regulates mammary gland development and luminal tumorigenesis |
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| Relations |
| BioProject |
PRJNA474002 |
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