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| Status |
Public on Dec 01, 2018 |
| Title |
Molecular basis of mitomycin C enhanced corneal sensory nerve repair |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We performed RNASeq and confocal imaging analysis to characterize the gene expression changes in the cornea after wounding that modulate sensory axon integrity. We show that by preserving the ability of axons to attach to one another and to corneal epithelial cells, mitomycin C enhances sensory nerve recovery after mechanical injury.
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| Overall design |
Epithelium and stroma from mouse corneas with/without Mitomycin C treatment and wounding were examined, 4 variables were tested (Control, Mitomycin C Control, Wound, Mitomycin C Wound).
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| Contributor(s) |
Morasso MI, Brooks SR, Stepp MA |
| Citation(s) |
30446696 |
| Submission date |
Jun 05, 2018 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Maria Irene Morasso |
| E-mail(s) |
morassom@mail.nih.gov
|
| Phone |
3014357842
|
| Organization name |
NIAMS NIH
|
| Lab |
Laboratory of Skin Biology
|
| Street address |
Bldg 50
|
| City |
Bethesda |
| State/province |
Maryland |
| ZIP/Postal code |
20892 |
| Country |
USA |
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| Platforms (1) |
| GPL21493 |
Illumina HiSeq 3000 (Mus musculus) |
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| Samples (32)
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| Relations |
| BioProject |
PRJNA474682 |
| SRA |
SRP149803 |
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