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Series GSE115940 Query DataSets for GSE115940
Status Public on Jun 19, 2018
Title p53 binding and chromatin dynamics after etoposide treatment of primary lung fibroblast
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
Summary We report the chromatin modification dynamics at p53 binding sites afte 6 hours of treatment of etoposide (100 micromolar final) in IMR90 human lung fibroblasts using ChIP-seq , ATAC-seq, and polyA+ RNA-seq analyses. We assessed the genomewide occupancy of histone H3, H3K4me3, H3K4me2, H3K4me1, H3K27ac, H4K16ac, RNA polymerase II, p53, and transposase-accessible chromatin (ATAC-seq) in response to etoposide treatment.
 
Overall design ChIP-seq, RNA-seq, and ATAC-seq for histone modifications, p53, and RNA polymerase II after etoposide treatment in IMR90 fetal lung fibroblasts
 
Contributor(s) Sammons M
Citation(s) 30966857
NIH grant(s)
Grant ID Grant title Affiliation Name
R15 GM128049 Molecular mechanisms regulating the establishment of cis-regulatory elements by the transcription factor p63 UNIVERSITY AT ALBANY, SUNY Morgan Andrew Sammons
Submission date Jun 18, 2018
Last update date Sep 13, 2019
Contact name Morgan A Sammons
E-mail(s) masammons@albany.edu
Organization name University at Albany - SUNY
Department Biological Sciences
Lab Sammons
Street address 1400 Washington Ave, Life Sciences 2075
City Albany
State/province NY
ZIP/Postal code 12222
Country USA
 
Platforms (2)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
Samples (11)
GSM3195619 ATAC_Etoposide
GSM3195620 Histone_H3_Etoposide
GSM3195621 H3K4me1_Etoposide
Relations
BioProject PRJNA476558
SRA SRP150762

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Supplementary file Size Download File type/resource
GSE115940_RAW.tar 464.9 Mb (http)(custom) TAR (of BEDGRAPH)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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