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| Status |
Public on Oct 18, 2018 |
| Title |
LGR5 promotes tumorigenicity and invasion of glioblastoma stem-like cells and is a potential therapeutic target for a subset of glioblastoma patients [oeLGR5] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Glioblastoma progression and recurrence are suggested to be derived by glioblastoma stem-like cells (GSCs). There is limited knowledge about the expression and therapy response of LGR5 in GSCs. We have investigated the role of LGR5 in glioblastoma by over-expression LGR5 using lentiviral vectors containing LGR5 cDNA (oeLGR5) or control (oeCTL).
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| Overall design |
Gene expression was analysed in two glioblastoma patient-derived GSC lines (U3020MG and U3060MG) transduced with lentiviral vectors containing oeLGR5 or oeCTL. All cells were cultured adherently under stem cell conditions.
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| Contributor(s) |
Xie Y, Sundström A, Maturi NP, Tan E, Marinescu VD, Jarvius M, Tirfing M, Jin C, Chen L, Essand M, Swartling FJ, Nelander S, Jiang Y, Uhrbom L |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Jun 19, 2018 |
| Last update date |
Oct 29, 2018 |
| Contact name |
Lene Uhrbom |
| Organization name |
Uppsala University
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| Department |
Immunology, Genetics and Pathology
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| Street address |
Dag Hammarskjölds väg 20
|
| City |
Uppsala |
| ZIP/Postal code |
75237 |
| Country |
Sweden |
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| Platforms (1) |
| GPL17586 |
[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version] |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA476791 |
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