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| Status |
Public on Jun 25, 2021 |
| Title |
Bag3-P209L RNA Seq Project |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Cardiac-specific Bag3-P209L transgenic (Tg+) mice develop dilated cardiomyopathy by 12 months of age. The goals of this project are to utilize RNA-sequencing to compare both cardiomyocyte and cardiac fibroblast transcriptomes between aged Bag3-P209L Tg+ and Bag3-WT mice to identify cardiomyocyte and fibroblast specific gene sets that contribute to the functional and morphological changes previously identified in Bag3-P209L Tg+ hearts.
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| Overall design |
Both cardiomyocytes and fibroblasts were isolated from three 16-month old Bag3-P209L Tg+ and three age matched Bag3-WT mice. RNA from cardiomyocytes and fibroblasts were then extracted and submitted to Novogene for cDNA library creation and subsequent RNA sequencing.
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| Contributor(s) |
Willis MS, Eaton SC |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Jun 25, 2018 |
| Last update date |
Jun 25, 2021 |
| Contact name |
Monte S Willis |
| E-mail(s) |
willisms@iu.edu
|
| Phone |
(317) 278-2674
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| Organization name |
University of Indiana School of Medicine
|
| Street address |
635 Barnhill Street Drive
|
| City |
Indianapolis |
| ZIP/Postal code |
IN 46202 |
| Country |
USA |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (18)
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| Relations |
| BioProject |
PRJNA477769 |
| SRA |
SRP151238 |
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