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| Status |
Public on Nov 19, 2018 |
| Title |
Bulk RNA-seq analysis of HUVEC cell cultures with Cerebral Cavernous Malformation (CCM) protein knockdown |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Gene expression profiles of WT (wild type) and CCM-1, -2, and -3 KD (knockdown of krit1, ccm2 and pdcd10 genes) cells under 2D (Matrigel-coated plastic) and 3D (Matrigel) conditions. Deep sequencing of RNA was performed for cells at the initial (2hrs) and later (6hrs) stages of EC tubule formation.
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| |
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| Overall design |
Comparative analysis of gene expression of healthy and diseased cells in the tube formation assay
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| |
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| Contributor(s) |
Chernaya O, Zhurikhina A, Hladyshau S, Pilcher W, Young KM, Ortner J, Andra V, Sulchek TA, Tsygankov D |
| Citation(s) |
30453164 |
| Submission date |
Jun 27, 2018 |
| Last update date |
Jan 02, 2019 |
| Contact name |
Denis Tsygankov |
| E-mail(s) |
denis.tsygankov@bme.gatech.edu
|
| Organization name |
Georgia Institute of Technology
|
| Department |
Biomedical Engineering
|
| Lab |
Integrative Systems Biology
|
| Street address |
North Ave NW
|
| City |
Atlanta |
| State/province |
GA |
| ZIP/Postal code |
30332 |
| Country |
USA |
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| Platforms (2) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA478141 |
| SRA |
SRP151417 |
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