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| Status |
Public on Apr 07, 2009 |
| Title |
Serial Analysis of Gene Expression molecular signature for disease progression in Idiopathic Pulmonary Fibrosis |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by SAGE
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| Summary |
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive fibrosing interstitial lung disease that is unresponsive to current therapy. While it carries a median survival of less than 3 years its rate of progression varies widely between patients. We hypothesized that studying the gene expression profiles of physiologically stable patients and those in which the disease progressed rapidly after the initial diagnosis would aid in the search for biomarkers and contribute to the understanding of disease pathogenesis.
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| Overall design |
We generated 12 Idiopathic Pulmonary Fibrosis (IPF) lung parenchyma SAGE profiles. Initial cluster analysis including 8 other public available lung SAGE libraries verified that the IPF transcriptome is distinct from normal lung tissue and other lung diseases like COPD. In order to identify candidate markers of disease progression we segregated the IPF SAGE profiles in two groups based on clinical parameters regarding lung volume and lung function.
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| Contributor(s) |
Boon K, Bailey NW, Yang J, Dolly K, Brown KK, David SA |
| Citation(s) |
19347046 |
| Submission date |
Jun 03, 2008 |
| Last update date |
Apr 18, 2012 |
| Contact name |
Kathy Boon |
| E-mail(s) |
boonc@nhlbi.nih.gov
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| Phone |
919-541-4288
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| Organization name |
NHLBI/NIEHS
|
| Department |
Division of Intramural Research
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| Lab |
Laboratory of Environmental Lung disease
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| Street address |
111 TW Alexander Dr
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| City |
Research Triangle Park |
| State/province |
NC |
| ZIP/Postal code |
27709 |
| Country |
USA |
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| Platforms (1) |
| GPL4 |
SAGE:10:NlaIII:Homo sapiens |
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| Samples (14)
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| Relations |
| BioProject |
PRJNA106179 |
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