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| Status |
Public on Oct 23, 2018 |
| Title |
Dysregulated neutrophil responses and neutrophil extracellular trap formation and degradation in PAPA syndrome |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Pyogenic arthritis, pyoderma gangrenosum and acne (PAPA) syndrome is characterized by flares of sterile arthritis with neutrophil infiltrate and the overproduction of Interleukin (IL)-1β. The purpose of this study was to elucidate the potential role of neutrophil subsets and neutrophil extracellular traps (NETs) in the pathogenesis of PAPA. The transcriptome of PAPA normal-dense neutrophils, autologous LDGs, and healthy control normal-dense neutrophils was characterized using RNASeq. The transcriptome of a PAPA skin biopsy and a healthy control skin sample was elucidated using RNASeq.
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| Overall design |
This dataset includes a total of 5 individual samples. This study sought to characterize PAPA normal-dense neutrophils, autologous LDGs, and healthy control normal-dense neutrophils and determine their transcriptomic profiles. We also wanted to characterize the transcriptomic profile of PAPA skin compared to a healthy control skin.
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| Contributor(s) |
Mistry P, Carmona-Rivera C, Seto N, Ombrello AK, Hoffmann P, Jones A, Stone DL, Carlucci PM, Dell'Orso S, Gutierrez-Cruz G, Sun HW, Kastner DL, Aksentijevich I, Kaplan MJ |
| Citation(s) |
30131320 |
| Submission date |
Jul 16, 2018 |
| Last update date |
Dec 23, 2018 |
| Contact name |
Hong-wei Sun |
| Organization name |
NIAMS
|
| Department |
Office of Science & Technology
|
| Lab |
Biodata Mining & Discovery Section
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| Street address |
9000 Rockville Pile
|
| City |
Bethesda |
| State/province |
MD |
| ZIP/Postal code |
20892 |
| Country |
USA |
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| Platforms (1) |
| GPL21290 |
Illumina HiSeq 3000 (Homo sapiens) |
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| Samples (5)
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| Relations |
| BioProject |
PRJNA481348 |
| SRA |
SRP153925 |
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