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| Status |
Public on Jan 23, 2019 |
| Title |
DNA hypermethylation encroachment at CpG island borders in cancer is predisposed by H3K4 monomethylation [mESC_WGBS] |
| Organism |
Mus musculus |
| Experiment type |
Methylation profiling by high throughput sequencing
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| Summary |
The crosstalk between H3K4 monomethylation and DNA methylation has been receiving little attention to date. We investigated DNA methylation profiles (using WGBS) of wild-type (WT) mouse ESCs, Mll3/Mll4 (Kmt2c/Kmt2d) mutant (dKO) ESCs and catalytic SET domain mutant (dCD) ESCs, which were kindly provided by the Wysocka Laboratory (Dorighi et al., 2017).
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| Overall design |
Genome-wide analysis of DNA methylation using WGBS in mouse wild-type ESCs (WT), Mll3/Mll4 (Kmt2c/Kmt2d) mutant (dKO) ESCs and catalytic SET domain mutant (dCD) ESC.
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| Contributor(s) |
Skvortsova K, Luu P, Clark SJ, Stirzaker C |
| Citation(s) |
30753827 |
| Submission date |
Aug 08, 2018 |
| Last update date |
Aug 12, 2019 |
| Contact name |
Ksenia Skvortsova |
| E-mail(s) |
k.skvortsova@garvan.org.au
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| Phone |
478135210
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| Organization name |
Garvan Institute
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| Department |
Genomics and Epigenetics
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| Lab |
Developmental Epigenomics
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| Street address |
384 Victoria St, Darlinghurst
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| City |
Sydney |
| State/province |
NSW |
| ZIP/Postal code |
2010 |
| Country |
Australia |
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| Platforms (1) |
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| Samples (3) |
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| This SubSeries is part of SuperSeries: |
| GSE104791 |
DNA hypermethylation encroachment at CpG island borders in cancer is predisposed by H3K4 mono-methylation patterns. |
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| Relations |
| BioProject |
PRJNA485157 |
| SRA |
SRP156779 |
