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| Status |
Public on Nov 28, 2018 |
| Title |
Aberrant expression of interleukin-23-regulated miRNAs in T cells from patients with ankylosing spondylitis |
| Organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by array
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| Summary |
Among the miRNAs regulated by IL-23, expression levels of 5 miRNAs were increased in T cells from patients with AS. The transfection of miR-29b-1-5p mimic could inhibit the IL-23-mediated STAT3 phosphorylation and might play a negative feedback control in the immunopathogenesis of AS.
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| Overall design |
K562 cells, a human erythroleukemia line, purchased from the American Type Culture Collection (Manassas, USA) were cultured in medium with or without the presence of IL-23 (20 ng/mL) for 3 days. These cells were used for subsequent analysis.
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| Contributor(s) |
Lai N, Yu H, Tung C, Huang K, Huang H, Lu M |
| Citation(s) |
30463609 |
| Submission date |
Aug 20, 2018 |
| Last update date |
Nov 28, 2018 |
| Contact name |
Hui Chun Yu |
| E-mail(s) |
junvsusagi@gmail.com
|
| Phone |
+886920179628
|
| Organization name |
Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
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| Department |
Medical research
|
| Street address |
No. 2, Min-Sheng Rd, Dalin Town
|
| City |
Chia-Yi |
| ZIP/Postal code |
62247 |
| Country |
Taiwan |
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| Platforms (1) |
| GPL24741 |
Agilent-070156 Human_miRNA_V21.0_Microarray 046064 (gene name version) |
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| Samples (6)
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| GSM3348020 |
Cells_coulture medium_3days, replicate 1 |
| GSM3348021 |
Cells_coulture medium_3days, replicate 2 |
| GSM3348022 |
Cells_coulture medium_3days, replicate 3 |
|
| Relations |
| BioProject |
PRJNA486828 |
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