|
| Status |
Public on May 17, 2019 |
| Title |
Immune Checkpoint Regulation of Pulmonary Fibrosis [bulk RNA-seq] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Fibroblasts from idiopathic pulmonary fibrosis (IPF) patients acquire an invasive phenotype that is essential for progressive fibrosis. The immune checkpoint ligand CD274 (PD-L1) is up-regulated on invasive lung fibroblasts, regulated by P53 and FAK signaling, and drives lung fibrosis in a humanized IPF model in mice. Targeting CD274high fibroblasts blunted invasion in vitro and attenuated fibrosis in vivo, suggesting that CD274 may be a novel therapeutic target in IPF.
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| |
|
| Overall design |
Reveal of the expression of the checkpoint PD1 ligand CD274 in invasive and non-invasive fibroblasts of both normal human lungs and IPF lungs
|
| |
|
| Contributor(s) |
Geng Y, Liu X, Liang J, Deng N, Wang Y, Jiang D, Noble PW |
| Citation(s) |
30763282, 35980387 |
| Submission date |
Aug 22, 2018 |
| Last update date |
Oct 26, 2022 |
| Contact name |
AGCT Core |
| Organization name |
Cedars Sinai Medical Center
|
| Department |
BMS
|
| Street address |
8687 Melrose Ave, PDC B230
|
| City |
West Hollywood |
| State/province |
CA |
| ZIP/Postal code |
90069 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL21290 |
Illumina HiSeq 3000 (Homo sapiens) |
|
| Samples (18)
|
|
| Relations |
| BioProject |
PRJNA487358 |
| SRA |
SRP158619 |
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