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Series GSE118950 Query DataSets for GSE118950
Status Public on Apr 15, 2020
Title Pathogenic Stem Cell Variation in Chronic Lung Disease
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Chronic obstructive lung disease is the third leading cause of death in the United States. We have identified and cloned the stem cell variants from patients lung samples using our cloning method. These stem cells functions are explored using combinations of microarray, single cell RNA-seq, ChIP-seq and in vivo assays.
Overall design We have cultured distal lung stem cells colony on 3T3 feeder layer. The stem cells are injected into mouse for the in vivo differentiation and mouse xenograft is used to examine the functional aspect of the stem cells. Microarray is performed for the stem cells and cells from the xenograft (Xeno) samples using Affymetrix human exon 1.0 st array chip.
Contributor(s) Rao W, Wang S, Mahalingam R, Xian W, McKeon F
Citation(s) 32298651
Submission date Aug 22, 2018
Last update date Jul 15, 2020
Contact name Frank McKeon
Phone 8608372486
Organization name University of Houston
Department Biology and Biochemistry
Street address 3455 Cullen Blvd
City Houston
State/province TX
ZIP/Postal code 77004
Country USA
Platforms (1)
GPL5175 [HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [transcript (gene) version]
Samples (9)
GSM3351774 patient SPN-12 xenograft 1
GSM3351775 patient SPN-12 xenograft 2
GSM3351785 patient SPN-13 xenograft B1
BioProject PRJNA487492

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE118950_RAW.tar 193.5 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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