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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Nov 10, 2008 |
| Title |
Expression data from LNCaP cells transfected with SOX4 cDNA, SOX4 siRNA or GFP cDNA |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
SOX4 is a critical developmental transcription factor in vertebrates and is required for precise differentiation and proliferation in multiple tissues. In addition, SOX4 is overexpressed in many human malignancies, but the precise role of SOX4 in cancer progression is not well understood. Here we have either eliminated SOX4 using siRNA or overexpressed a SOX4 cDNA and compared the gene expression patterns against control GFP transfections to identify SOX4 target genes.
Data described in manuscript P. Liu et al., Cancer Res 46, 4011 (April 15, 2006)
Keywords: Gene Expression
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| Overall design |
LNCaP prostate cancer cells were transfected with either a SOX4 cDNA, a pool of SOX4 siRNAs or a control GFP expression vector. Each transfection was performed in duplicate on two separate days. Total RNA was harvested 24 hours post-transfection
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| Contributor(s) |
Moreno CS, Scharer C |
| Citation(s) |
19147588 |
| Submission date |
Jun 27, 2008 |
| Last update date |
Aug 10, 2018 |
| Contact name |
Chris Scharer |
| E-mail(s) |
cdschar@emory.edu
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| Organization name |
Emory University
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| Department |
Microbiology and Immunology
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| Lab |
Chris Scharer
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| Street address |
1510 Clifton Rd, Suite 3086A
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| City |
Atlanta |
| State/province |
GA |
| ZIP/Postal code |
30322 |
| Country |
USA |
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| Platforms (2) |
| GPL96 |
[HG-U133A] Affymetrix Human Genome U133A Array |
| GPL97 |
[HG-U133B] Affymetrix Human Genome U133B Array |
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| Samples (12)
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| GSM301123 |
LNCaP - SOX4 cDNA, Day2, U133A |
| GSM301124 |
LNCaP - SOX4 siRNA, Day1, U133A |
| GSM301125 |
LNCaP - SOX4 siRNA, Day2, U133A |
| GSM301126 |
LNCaP - GFP, Day1, U133B |
| GSM301127 |
LNCaP - GFP, Day2, U133B |
| GSM301128 |
LNCaP - SOX4 cDNA, Day1, U133B |
| GSM301129 |
LNCaP - SOX4 cDNA, Day2, U133B |
| GSM301130 |
LNCaP - SOX4 siRNA, Day1, U133B |
| GSM301131 |
LNCaP - SOX4 siRNA, Day2, U133B |
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| This SubSeries is part of SuperSeries: |
| GSE11915 |
SOX4 effect on LNCaP prostate cancer cells |
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| Relations |
| BioProject |
PRJNA109247 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE11914_RAW.tar |
41.2 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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