|
| Status |
Public on May 07, 2021 |
| Title |
Regulation of TLR8-activated gene expression in human neutrophils [RNA-seq neutrophils & monocytes] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
The transcription factors that regulate gene expression in stimulated neutrophils are poorly characterized. Herein, we found that the genomic distribution of the myeloid lineage determining transcription factors PU.1 and C/EBPβ, as well as that of the histone modification H3K27Ac, which marks active chromatin, significantly change in human neutrophils treated with R848, a ligand of TLR8.
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| |
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| Overall design |
Examination of histone modification, transcription factor binding and transcriptome in human neutrophils and granulocytic-differentiated HL-60 cell line
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| |
|
| Contributor(s) |
Bianchetto-Aguilera F, Tamassia N, Natoli G, Cassatella MA |
| Citation missing |
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| Submission date |
Sep 03, 2018 |
| Last update date |
May 07, 2021 |
| Contact name |
Francisco Miguel Angel Bianchetto-Aguilera |
| E-mail(s) |
franciscomiguelangel.bianchettoaguilera@univr.it
|
| Phone |
+390458027259
|
| Organization name |
University of Verona
|
| Department |
Department of Medicine
|
| Lab |
Marco Cassatella
|
| Street address |
Strade le Grazie, 8
|
| City |
Verona |
| State/province |
VR |
| ZIP/Postal code |
37134 |
| Country |
Italy |
| |
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| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
|
| Samples (24)
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| This SubSeries is part of SuperSeries: |
| GSE119395 |
Regulation of TLR8-activated gene expression in human neutrophils |
|
| Relations |
| BioProject |
PRJNA489111 |
| SRA |
SRP159474 |
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