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Series GSE119407 Query DataSets for GSE119407
Status Public on Jun 21, 2019
Title The role of TERF2IP (Telomeric repeat binding factor 2-interacting protein) in regulating disturbed flow-induced changes of gene expression
Organism Homo sapiens
Experiment type Expression profiling by array
Summary To understand the function of TERF2IP in ECs, we isolated total RNAs from human aortic endothelial cells (HAECs) transfected with control or TERF2Ip siRNA and transcriptionally profiled them.
 
Overall design HAECs were transfected by control siRNA or TERF2IP siRNA, and after 48 hrs of transfection HUVECs were exposed to disturbed flow (d-flow). After 24 hrs of disturbed flow RNA was extracted for futher microarray processing. We have the following four groups (1. Control siRNA under static condition (siCont), 2. Control siRNA under d-flow (siCont + DF), 3. TERF2IP siRNA under d-flow (siTERF2IP), and 4. TERF2IP siRNA under d-flow (siTERF2IP + DF), and each group have three samples and total twelve samples were analyzed.
 
Contributor(s) Abe J, Le N, Lusis AJ
Citation(s) 31045573
Submission date Sep 04, 2018
Last update date Jun 21, 2019
Contact name Jun-ichi Abe
E-mail(s) jabe@mdanderson.org
Phone 5854745456
Organization name University of Texas MD Anderson Cacer Center
Street address 2121 W Holcombe Blvd. IBT8 803e
City Houston
State/province Texas
ZIP/Postal code 77030
Country USA
 
Platforms (1)
GPL17586 [HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
Samples (12)
GSM3374267 HAECs siCont rep1
GSM3374268 HAECs siCont rep2
GSM3374269 HAECs siCont rep3
Relations
BioProject PRJNA489190

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE119407_DF_TERF2IP.txt.gz 2.9 Mb (ftp)(http) TXT
GSE119407_RAW.tar 293.8 Mb (http)(custom) TAR (of CEL, CHP)
Processed data included within Sample table
Processed data provided as supplementary file
Processed data are available on Series record

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