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Status |
Public on Sep 03, 2019 |
Title |
Interaction between oncogenic FREM2 with IL-1β signaling contributes to esophageal squamous cell carcinoma progression |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
Inflammatory signals can promote tumorigenesis. The pro-inflammatory cytokine interleukin (IL)-1β is overexpressed in many types of tumor; however, it is unclear whether it directly interacted with oncogenes in esophageal squamous cell carcinoma. In this study, we performed RNA sequencing to identify tumorgenesis and recurrence-related factors in ESCC and identified FRAS1-related extracellular matrix protein (FREM)2 as a candidate oncogene. IL-1β and IL-1R1 were upregulated in ESCC tissue, which was accompanied by elevated Frem2 expression. FREM2 formed complex with IL-1R1 at the cell surface and promoted ESCC cell proliferation and migration via activation of nuclear factor-κB–p65/mitogen-activated protein kinase–c-Jun N-terminal kinase signaling. IL-1β stimulation resulted in the upregulation of FREM2 in ESCC cells through inhibition of Forkhead box P1. Increased FREM2 and IL-1R1 levels were correlated with shorter survival time in ESCC patients.
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Overall design |
RNA profiles of tumor tissues and paired normal tissues from 4 ESCC patients were generated by sequencing
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Contributor(s) |
Wang L, Lin Z |
Citation missing |
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Submission date |
Sep 04, 2018 |
Last update date |
Sep 03, 2019 |
Contact name |
Lin Wang |
E-mail(s) |
wanglin_97@hotmail.com
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Organization name |
Zhongshan Hospital, Fudan University
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Department |
Department of thoracic surgery
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Street address |
180 Fenglin Rd.
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City |
Shanghai |
ZIP/Postal code |
200032 |
Country |
China |
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Platforms (1) |
GPL9052 |
Illumina Genome Analyzer (Homo sapiens) |
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Samples (8)
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Relations |
BioProject |
PRJNA489250 |
SRA |
SRP159526 |