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Series GSE119436 Query DataSets for GSE119436
Status Public on Sep 03, 2019
Title Interaction between oncogenic FREM2 with IL-1β signaling contributes to esophageal squamous cell carcinoma progression
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Inflammatory signals can promote tumorigenesis. The pro-inflammatory cytokine interleukin (IL)-1β is overexpressed in many types of tumor; however, it is unclear whether it directly interacted with oncogenes in esophageal squamous cell carcinoma. In this study, we performed RNA sequencing to identify tumorgenesis and recurrence-related factors in ESCC and identified FRAS1-related extracellular matrix protein (FREM)2 as a candidate oncogene. IL-1β and IL-1R1 were upregulated in ESCC tissue, which was accompanied by elevated Frem2 expression. FREM2 formed complex with IL-1R1 at the cell surface and promoted ESCC cell proliferation and migration via activation of nuclear factor-κB–p65/mitogen-activated protein kinase–c-Jun N-terminal kinase signaling. IL-1β stimulation resulted in the upregulation of FREM2 in ESCC cells through inhibition of Forkhead box P1. Increased FREM2 and IL-1R1 levels were correlated with shorter survival time in ESCC patients.
 
Overall design RNA profiles of tumor tissues and paired normal tissues from 4 ESCC patients were generated by sequencing
 
Contributor(s) Wang L, Lin Z
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Submission date Sep 04, 2018
Last update date Sep 03, 2019
Contact name Lin Wang
E-mail(s) wanglin_97@hotmail.com
Organization name Zhongshan Hospital, Fudan University
Department Department of thoracic surgery
Street address 180 Fenglin Rd.
City Shanghai
ZIP/Postal code 200032
Country China
 
Platforms (1)
GPL9052 Illumina Genome Analyzer (Homo sapiens)
Samples (8)
GSM3374665 N1
GSM3374666 N4
GSM3374667 N5
Relations
BioProject PRJNA489250
SRA SRP159526

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE119436_All_Counts.txt.gz 489.4 Kb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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