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| Status |
Public on Jul 10, 2008 |
| Title |
mouse lung resistance or sensitivity to cigarette smoke |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
We have investigated the effects of cigarette smoke exposure in three different strains of mice. DBA/2 and C57Bl/6J are susceptible to smoke and develop different lung changes in response to chronic exposure, while ICR mice are resistant to smoke and do not develop emphysema. The present study was carried out to determine early changes in the gene expression profile of mice exposed to cigarette smoke with either a susceptible or resistant phenotype.
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| Overall design |
Three strains of mice were exposed to smoke from three cigarette/day, 5d/wk for 4 weeks. Microarray analysis was carried out on total RNA extracted from the lung utilizing the Affymetrix platform.
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| Contributor(s) |
Cavarra E, Ricciardi A, Fineschi S, Fardin P, De Cunto G, Sallustio F, Zorzetto M, Luisetti M, Pfeffer U, Lungarella G, Varesio L |
| Citation(s) |
19118092 |
| Submission date |
Jul 08, 2008 |
| Last update date |
Feb 18, 2018 |
| Contact name |
Paolo Fardin |
| E-mail(s) |
paolofardin@ospedale-gaslini.ge.it
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| Organization name |
Istiuto Giannina Gaslini
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| Department |
Molecular Biology
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| Street address |
Largo G. Gaslini 5
|
| City |
Genoa |
| ZIP/Postal code |
16147 |
| Country |
Italy |
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| Platforms (1) |
| GPL81 |
[MG_U74Av2] Affymetrix Murine Genome U74A Version 2 Array |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA113355 |
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