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Series GSE12036 Query DataSets for GSE12036
Status Public on Jul 10, 2008
Title mouse lung resistance or sensitivity to cigarette smoke
Organism Mus musculus
Experiment type Expression profiling by array
Summary We have investigated the effects of cigarette smoke exposure in three different strains of mice. DBA/2 and C57Bl/6J are susceptible to smoke and develop different lung changes in response to chronic exposure, while ICR mice are resistant to smoke and do not develop emphysema. The present study was carried out to determine early changes in the gene expression profile of mice exposed to cigarette smoke with either a susceptible or resistant phenotype.
Overall design Three strains of mice were exposed to smoke from three cigarette/day, 5d/wk for 4 weeks. Microarray analysis was carried out on total RNA extracted from the lung utilizing the Affymetrix platform.
Contributor(s) Cavarra E, Ricciardi A, Fineschi S, Fardin P, De Cunto G, Sallustio F, Zorzetto M, Luisetti M, Pfeffer U, Lungarella G, Varesio L
Citation(s) 19118092
Submission date Jul 08, 2008
Last update date Feb 18, 2018
Contact name Paolo Fardin
Organization name Istiuto Giannina Gaslini
Department Molecular Biology
Street address Largo G. Gaslini 5
City Genoa
ZIP/Postal code 16147
Country Italy
Platforms (1)
GPL81 [MG_U74Av2] Affymetrix Murine Genome U74A Version 2 Array
Samples (6)
GSM304268 C57 control mouse_1
GSM304269 C57 smoked mouse_1
GSM304278 DBA control mouse_1
BioProject PRJNA113355

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Supplementary file Size Download File type/resource
GSE12036_RAW.tar 43.6 Mb (http)(custom) TAR (of CEL, CHP)
Raw data provided as supplementary file
Processed data included within Sample table

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