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| Status |
Public on Sep 23, 2019 |
| Title |
Selective eradication of leukemia cells with reprogramming factors (ATAC-Seq) |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
We used ATAC-seq to evaluate the global programme of chromtain accessibility after Dox inducible Yamanaka factors ectopic expression during this biological process.
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| Overall design |
To investigate the chromatin accessibility changes for the elimination of leukemia cells after Dox inducible Yamanaka factors (Oct4,Sox2,Klf4,c-Myc) expression, we sorted GFP+ MLL-AF9 acute myeloid leukemia cells (MLL-AF9) from leukemic mice and normal c-kit+ cells (WT) from 4F transgenic mice. Leukemia cells and ckit+ cells were sorted from distinct groups at different time points
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| Contributor(s) |
Lu T, Cheng H |
| Citation(s) |
31811153 |
| Submission date |
Oct 11, 2018 |
| Last update date |
Dec 17, 2019 |
| Contact name |
Kuangyu Yen |
| E-mail(s) |
kuangyuyen@ihcams.ac.cn
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| Organization name |
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
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| Department |
State Key Laboratory of Experimental Hematology
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| Street address |
Nanjing Road
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| City |
Tianjin |
| ZIP/Postal code |
300020 |
| Country |
China |
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| Platforms (1) |
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| Samples (36)
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| This SubSeries is part of SuperSeries: |
| GSE121123 |
Selective eradication of leukemia cells with reprogramming factors |
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| Relations |
| BioProject |
PRJNA495799 |
| SRA |
SRP165195 |
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