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GEO help: Mouse over screen elements for information. |
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Status |
Public on Nov 30, 2018 |
Title |
Expression data from testis in mutant mouse lacking retinoic acid synthesizing enzymes in germ cells |
Organism |
Mus musculus |
Experiment type |
Expression profiling by array
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Summary |
In mammals, all-trans retinoic acid (ATRA) is instrumental to spermatogenesis. It is synthesized by two retinaldehyde dehydrogenases (RALDH) present notably in germ cells (GC). In order to determine the contributions of the GC-derived source of ATRA, we have generated mice lacking all RALDH activities in GC. We show that the GC-derived source of ATRA does not perform any specific role despite contributing to two-third of the total amount of ATRA present in the testis.
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Overall design |
Mice carrying loxP-flanked alleles (L2) of Aldh1a1(tm1Nbg), Aldh1a2 and Aldh1a3(tm1Pcn) were crossed with mice bearing the Tg(Stra8-cre)1Reb transgene. Testis were sampled for analysis at the age of 9 weeks.
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Contributor(s) |
Mark M, Ghyselinck NB |
Citation(s) |
30487180 |
Submission date |
Oct 16, 2018 |
Last update date |
Feb 14, 2019 |
Contact name |
Norbert B. GHYSELINCK |
E-mail(s) |
norbert@igbmc.fr
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Organization name |
Institut de Genetique et Biologie Moleculaire et Cellulaire (IGBMC)
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Department |
Functional Genomics and Cancer
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Lab |
MARK-GHYSELINCK
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Street address |
4 rue Laurent Fries
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City |
ILLKIRCH CEDEX |
ZIP/Postal code |
F-67404 |
Country |
France |
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Platforms (1) |
GPL23038 |
[Clariom_S_Mouse] Affymetrix Clariom S Assay, Mouse (Includes Pico Assay) |
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Samples (6)
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Relations |
BioProject |
PRJNA497066 |
Supplementary file |
Size |
Download |
File type/resource |
GSE121326_RAW.tar |
8.1 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
Processed data included within Sample table |
Processed data provided as supplementary file |
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