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Series GSE121326 Query DataSets for GSE121326
Status Public on Nov 30, 2018
Title Expression data from testis in mutant mouse lacking retinoic acid synthesizing enzymes in germ cells
Organism Mus musculus
Experiment type Expression profiling by array
Summary In mammals, all-trans retinoic acid (ATRA) is instrumental to spermatogenesis. It is synthesized by two retinaldehyde dehydrogenases (RALDH) present notably in germ cells (GC). In order to determine the contributions of the GC-derived source of ATRA, we have generated mice lacking all RALDH activities in GC.
We show that the GC-derived source of ATRA does not perform any specific role despite contributing to two-third of the total amount of ATRA present in the testis.
 
Overall design Mice carrying loxP-flanked alleles (L2) of Aldh1a1(tm1Nbg), Aldh1a2 and Aldh1a3(tm1Pcn) were crossed with mice bearing the Tg(Stra8-cre)1Reb transgene. Testis were sampled for analysis at the age of 9 weeks.
 
Contributor(s) Mark M, Ghyselinck NB
Citation(s) 30487180
Submission date Oct 16, 2018
Last update date Feb 14, 2019
Contact name Norbert B. GHYSELINCK
E-mail(s) norbert@igbmc.fr
Organization name Institut de Genetique et Biologie Moleculaire et Cellulaire (IGBMC)
Department Functional Genomics and Cancer
Lab MARK-GHYSELINCK
Street address 4 rue Laurent Fries
City ILLKIRCH CEDEX
ZIP/Postal code F-67404
Country France
 
Platforms (1)
GPL23038 [Clariom_S_Mouse] Affymetrix Clariom S Assay, Mouse (Includes Pico Assay)
Samples (6)
GSM3431481 Testis, control, biological rep1
GSM3431482 Testis, control, biological rep2
GSM3431483 Testis, control, biological rep3
Relations
BioProject PRJNA497066

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE121326_RAW.tar 8.1 Mb (http)(custom) TAR (of CEL, CHP)
Processed data included within Sample table
Processed data provided as supplementary file

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